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The role of c1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during helicobacter pylori infection
(Springer Nature, 2015-09-08)
Background: Gastric epithelial cells (GECs) undergo apoptosis during H. pylori infection and phagocytes within the mucosa engulf these cells. The recognition and clearance of apoptotic cells is a multifactorial process, ...
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies
(Oxford University Press (OUP), 2011-07-01)
Retinoblastoma protein (pRb) is a ubiquitous 928-amino acid cell cycle regulatory molecule with diverse biologic activities. One critical function of pRb is the control of the G(1)-to-S phase checkpoint of the cell cycle. ...
Fasciola hepaticasurface tegument: glycoproteins at the interface of parasite and host
(American Society for Biochemistry & Molecular Biology (ASBMB), 2016-07-27)
Fasciola hepatica, commonly known as liver fluke, is a trematode that causes Fasciolosis in ruminants and humans. The outer tegumental coat of F. hepatica (FhTeg) is a complex metabolically active biological matrix that ...
Presence of terminal n-acetylgalactosamineβ1-4n-acetylglucosamine residues on o-linked oligosaccharides from gastric muc5ac: involvement in helicobacter pylori colonization?
(Oxford University Press (OUP), 2012-04-26)
Isolation of MUC5AC mucins from the gastric mucosa from two secretor individuals (one from normal mucosa from a patient with gastric cancer and one from a control) showed different abilities to bind and induce the proliferation ...
Newly identified genetic risk variants for celiac disease related to the immune response
(Springer Nature, 2008-03-02)
Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in ...
Targeting the pim kinases in multiple myeloma
(Springer Nature, 2015-07-17)
Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The Pims are a small family of serine/threonine kinases with increased expression ...
New roles for nanos in neural cell fate determination revealed by studies in a cnidarian
(The Company of Biologists, 2013-05-09)
Nanos is a pan-metazoan germline marker, important for germ cell development and maintenance. In flies, Nanos also acts in posterior and neural development, but these functions have not been demonstrated experimentally in ...
Salivary muc7 is a major carrier of blood group i type o-linked oligosaccharides serving as the scaffold for sialyl lewis x
(Oxford University Press (OUP), 2008-11-29)
Isolation of salivary MUC7 with gel electrophoresis allowed analysis by LC-MS and LC-MS(2) of released O-linked oligosaccharides and a thorough description of the glycosylation of this molecule, where high-molecular-weight ...
<i>phip</i> - a novel candidate breast cancer susceptibility locus on 6q14.1
(Impact Journals, LLC, 2017-11-28)
Most non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent ...
Towards precision medicine: discovering novel gynecological cancer biomarkers and pathways using linked data
(Springer Nature, 2017-09-19)
Background: Next Generation Sequencing (NGS) is playing a key role in therapeutic decision making for the cancer prognosis and treatment. The NGS technologies are producing a massive amount of sequencing datasets. Often, ...