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Identification of broadly neutralizing antibody epitopes in the hiv-1 envelope glycoprotein using evolutionary models
(Springer Nature, 2013-01-01)
Background: Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine.
Methods: We have developed a computational ...
Discovery of a new tev gamma-ray source: ver j0521+211
(IOP Publishing, 2013-09-27)
We report the detection of a new TeV gamma-ray source, VER J0521+211, based on observations made with the VERITAS imaging atmospheric Cherenkov Telescope Array. These observations were motivated by the discovery of a cluster ...
Applying current screening tools for gestational diabetes mellitus to a european population: is it time for change?
(American Diabetes Association, 2013-06-11)
OBJECTIVEThe optimal screening regimen for gestational diabetes mellitus (GDM) remains controversial. Risk factors used in selective screening guidelines vary. Given that universal screening is not currently adopted in our ...
Veritas observations of the microquasar cygnus x-3
(IOP Publishing, 2013-12-03)
We report results from TeV gamma-ray observations of the microquasar Cygnus X-3. The observations were made with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) over a time period from 2007 June 11 ...
Long term observations of b2 1215+30 with veritas
(IOP Publishing, 2013-11-27)
We report on VERITAS observations of the BL Lac object B2 1215+30 between 2008 and 2012. During this period, the source was detected at very high energies (VHEs; E > 100 GeV) by VERITAS with a significance of 8.9s ...
Long-term tev and x-ray observations of the gamma-ray binary hess j0632+057
(IOP Publishing, 2013-12-20)
HESS J0632+057 is the only gamma-ray binary known so far whose position in the sky allows observations with ground-based observatories in both the northern and southern hemispheres. Here we report on long-term observations ...
The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis
(Cambridge University Press (CUP), 2013-11-28)
Background. Genetic studies of single gene variants have been criticized as providing a simplistic characterization of the genetic basis of illness risk that ignores the effects of other variants within the same biological ...
Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the world society of the abdominal compartment syndrome
(Springer Nature, 2013-05-15)
To update the World Society of the Abdominal Compartment Syndrome (WSACS) consensus definitions and management statements relating to intra-abdominal hypertension (IAH) and the abdominal compartment syndrome (ACS).
We ...
Comparison of viral env proteins from acute and chronic infections with subtype c human immunodeficiency virus type 1 identifies differences in glycosylation and ccr5 utilization and suggests a new strategy for immunogen design
(American Society for Microbiology, 2013-04-24)
Understanding human immunodeficiency virus type 1 (HIV-1) transmission is central to developing effective prevention strategies, including a vaccine. We compared phenotypic and genetic variation in HIV-1 env genes from ...
The cost-effectiveness of a structured education pulmonary rehabilitation programme for chronic obstructive pulmonary disease in primary care: the prince cluster randomised trial
(BMJ, 2013-11-01)
Objective To assess the cost-effectiveness of a structured education pulmonary rehabilitation programme (SEPRP) for chronic obstructive pulmonary disease (COPD) relative to usual practice in primary care. The programme ...