Now showing items 1-2 of 2

    • Oscillation of apc/c activity during cell cycle arrest promotes centrosome amplification 

      Prosser, Suzanna L.; Samant, Mugdha D.; Baxter, Joanne E.; Morrison, Ciaran G.; Fry, Andrew M. (The Company of Biologists, 2012-09-06)
      Centrosome duplication is licensed by the disengagement, or 'uncoupling', of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature ...
    • Xrcc1 interacts with the p58 subunit of dna pol α-primase and may coordinate dna repair and replication during s phase 

      Lévy, Nicolas; Oehlmann, Maren; Delalande, François; Nasheuer, Heinz-Peter; Van Dorsselaer, Alain; Schreiber, Valérie; de Murcia, Gilbert; Ménissier-de Murcia, Josiane; Maiorano, Domenico; Bresson, Anne (Oxford University Press (OUP), 2009-03-21)
      Repair of single-stranded DNA breaks before DNA replication is critical in maintaining genomic stability; however, how cells deal with these lesions during S phase is not clear. Using combined approaches of proteomics and ...