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    • Ddk dependent regulation of top2a at centromeres revealed by a chemical genetics approach 

      Wu, Kevin Z. L.; Wang, Guan-Nan; Fitzgerald, Jennifer; Quachthithu, Huong; Rainey, Michael D.; Cattaneo, Angela; Bachi, Angela; Santocanale, Corrado (Oxford University Press (OUP), 2016-07-12)
      In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and its depletion sensitises ...