Now showing items 3234-3253 of 4432

    • Rational design and validation of a tip60 histone acetyltransferase inhibitor 

      Gao, Chunxia; Bourke, Emer; Scobie, Martin; Famme, Melina Arcos; Koolmeister, Tobias; Helleday, Thomas; Eriksson, Leif A.; Lowndes, Noel F.; Brown, James A. L. (Springer Nature, 2014-06-20)
      Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone ...
    • Rationale, design and baseline characteristics of participants in the c ardiovascular o utco m es for p eople using a nticoagulation s trategie s (compass) trial 

      Bosch, Jackie; Eikelboom, John W.; Connolly, Stuart J.; Bruns, Nancy Cook; Lanius, Vivian; Yuan, Fei; Misselwitz, Frank; Chen, Edmond; Diaz, Rafael; Alings, Marco; Lonn, Eva M.; Widimsky, Petr; Hori, Masatsugu; Avezum, Alvaro; Piegas, Leopoldo S.; Bhatt, Deepak L.; Branch, Kelley R.H.; Probstfield, Jeffrey L.; Liang, Yan; Liu, Lisheng; Zhu, Jun; Maggioni, Aldo P.; Lopez-Jaramillo, Patricio; O'Donnell, Martin; Fox, Keith A.A.; Kakkar, Ajay; Parkhomenko, Alexander N.; Ertl, Georg; Störk, Stefan; Keltai, Katalin; Keltai, Matyas; Ryden, Lars; Dagenais, Gilles R.; Pogosova, Nana; Dans, Antonio L.; Lanas, Fernando; Commerford, Patrick J.; Torp-Pedersen, Christian; Guzik, Tomasz J.; Verhamme, Peter B.; Vinereanu, Dragos; Kim, Jae-Hyung; Ha, Jong-Won; Tonkin, Andrew M.; Varigos, John D.; Lewis, Basil S.; Felix, Camilo; Yusoff, Khalid; Steg, Philippe Gabriel; Aboyans, Victor; Metsarinne, Kaj P.; Anand, Sonia S.; Hart, Robert G.; Lamy, Andre; Moayyedi, Paul; Leong, Darryl P.; Sharma, Mukul; Yusuf, Salim (Elsevier BV, 2017-08-01)
      Background: Long-term aspirin prevents vascular events but is only modestly effective. Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone for vascular prevention in patients with ...
    • Re-constructing the urban landscape through community mapping: an attractive prospect for sustainability? 

      Fahy, Frances; Cinnéide, Micheál Ó (Wiley-Blackwell, 2009-06-01)
      Community mapping is a relatively new tool with considerable potential in giving practical effect at the local level to sustainable development rhetoric. As a repository of socially constructed knowledge, it has considerable ...
    • Reactivation of phosphorus in sediments after calcium-rich mineral capping: implication for revising the laboratory testing scheme for immobilization efficiency 

      Ding, Shiming; Chen, Musong; Cui, Jingzhen; Wang, Dan; Lin, Juan; Zhang, Chaosheng; Tsang, Daniel C.W. (Elsevier BV, 2017-09-01)
      The efficiencies of capping agents in immobilizing sediment phosphorus (P) are widely assessed using a short-term batch adsorption method. This is done based upon the assumption that the immobilization process can be ...
    • Reactivity of inorganic mn and mn desferrioxamine b with o2, o2–, and h2o2in seawater 

      Wuttig, Kathrin; Heller, Maija I.; Croot, Peter L. (American Chemical Society (ACS), 2013-08-22)
      Manganese (Mn) is a required element for oceanic phytoplankton as it plays a critical role in photosynthesis, through its unique redox chemistry, as the active site in photosystem II, and in enzymes that act as defenses ...
    • Readability and content of patient information leaflets for endoscopic procedures 

      Gargoum, F. S.; O’Keeffe, S. T. (Springer Nature, 2013-10-31)
      Informed consent requires good communication. Patient information leaflets (PILs) may be helpful, although some PILs are too hard to read for the average patient. We sought to examine the readability of PILs provided for ...
    • Real-time monitoring of concrete–lattice-girder slabs during construction 

      Newell, Shane; Goggins, Jamie (Thomas Telford Ltd., 2017-06-06)
      This paper reports on the instrumentation, monitoring and some preliminary results from a real-time monitoring scheme of a hybrid concrete-lattice-girder slab flooring system. One of the key benefits of this monitoring ...
    • Real-time pcr detection of dinophysis species in irish coastal waters 

      Kavanagh, Siobhán; Brennan, Claire; O’Connor, Louise; Moran, Siobhán; Salas, Rafael; Lyons, Josephine; Silke, Joe; Maher, Majella (Springer Nature, 2009-11-28)
      Diarrhetic shellfish toxin-producing Dinophysis species occur in Irish coastal waters throughout the year. Dinophysis acuta and Dinophysis acuminata are the most commonly occurring species and are responsible for the ...
    • Realizing fusion systems inside finite groups 

      Park, Sejong (American Mathematical Society (AMS), 2016-03-17)
      We show that every (not necessarily saturated) fusion system can be realized as a full subcategory of the fusion system of a finite group. This result extends our previous work from 2010 and complements the related result ...
    • Reasons for participation and non-participation in a diabetes prevention trial among women with prior gestational diabetes mellitus (gdm) 

      Infanti, Jennifer J; O’Dea, Angela; Gibson, Irene; McGuire, Brian E; Newell, John; Glynn, Liam G; O’Neill, Ciaran; Connolly, Susan B; Dunne, Fidelma P (Springer Nature, 2014-01-24)
      Background: Gestational diabetes mellitus (GDM) is a risk factor for the development of type 2 diabetes. Lifestyle intervention can prevent progression to type 2 diabetes in high risk populations. We designed a randomised ...
    • Recent advances in employing molecular modelling to determine the specificity of glycan-binding proteins 

      Grant, Oliver C; Woods, Robert J (Elsevier BV, 2014-10-01)
      Impressive improvements in docking performance can be achieved by applying energy bonuses to poses in which glycan hydroxyl groups occupy positions otherwise preferred by bound waters. In addition, inclusion of glycosidic ...
    • Recent advances in psychoneuroimmunology: inflammation in psychiatric disorders 

      Debnath, Monojit; Doyle, Karen M.; Langan, Camilla; McDonald, Colm; Leonard, Brian; Cannon, Dara (Walter de Gruyter GmbH, 2011-01-01)
      Psychiatric disorders are common and complex and their precise biological underpinnings remain elusive. Multiple epidemiological, molecular, genetic and gene expression studies suggest that immune system dysfunction may ...
    • Recent data suggest no further recovery in north sea large fish indicator 

      Fung, T.; Farnsworth, K. D.; Reid, D. G.; Rossberg, A. G. (Oxford University Press (OUP), 2012-01-12)
      We detail the calculations of North Sea Large Fish Indicator values for 2009-2011, demonstrating an apparent stall in recovery. Therefore, recovery to the Marine Strategy Framework Directive's good environmental status of ...
    • Recent trends in boundary value problems 

      Ahmad, Bashir; Nieto, Juan J.; O'Regan, Donal; Zafer, Agacik (Hindawi Limited, 2013-01-01)
    • Recent trends in clot retrieval devices: a review 

      Hameed, Aamir; Zafar, Haroon; Mylotte, Darren; Sharif, Faisal (Springer Nature, 2017-07-12)
      Stroke is the second leading cause of death worldwide and in Europe. Even with gold standard medical management of acute ischemic stroke, which is intravenous (IV) thrombolysis by administration of recombinant tissue ...
    • Recognizing finite matrix groups over infinite fields 

      Detinko, A.S.; Flannery, D.L.; OʼBrien, E.A. (Elsevier BV, 2013-03-01)
    • Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice 

      Rosberg-Cody, E.; Stanton, C.; O'Mahony, L.; Wall, R.; Shanahan, F.; Quigley, E. M.; Fitzgerald, G. F.; Ross, R. P. (Microbiology Society, 2010-12-22)
      We have previously demonstrated that oral administration of a metabolically active Bifidobacterium breve strain, with ability to form cis-9, trans-11 conjugated linoleic acid (CLA), resulted in modulation of the fatty acid ...
    • Recombination-mediated remodelling of host–pathogen interactions during staphylococcus aureus niche adaptation 

      Spoor, Laura E.; Ross Fitzgerald, J.; Nutbeam-Tuffs, Stephen; Richardson, Emily; Wilson, Gillian J.; O'Gara, James P.; Corander, Jukka; McAdam, Paul R.; Richards, Amy C.; Lee, Chia Y.; Black, Nikki S.; Gupta, Ravi Kr.; Mendonca, Chriselle (Microbiology Society, 2015-10-13)
      Large-scale recombination events have led to the emergence of epidemic clones of several major bacterial pathogens. However, the functional impact of the recombination on clonal success is not understood. Here, we identified ...
    • Reconciling probability theory and coherentism 

      Duddy, Conal (Springer Nature, 2013-06-27)
      Recent results in the literature appear to show that it is impossible for two independent testimonies to jointly raise the probability of a proposition if neither testimony individually has any impact on that probability. ...
    • Reconsultation and antimicrobial treatment of urinary tract infection in male and female patients in general practice 

      Tandan, Meera; Duane, Sinead; Cormican, Martin; Murphy, Andrew; Vellinga, Akke (MDPI AG, 2016-09-15)
      Current antimicrobial prescribing guidelines indicate that male and female patients with urinary tract infections (UTIs) should be treated with same antimicrobials but for different durations. The aim of this study was to ...