Browsing by Author "Caffrey, Emer"
Now showing items 1-3 of 3
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Oestrogen-dependent regulation of mirna biogenesis: many ways to skin the cat
Gupta, Ananya; Caffrey, Emer; Callagy, Grace; Gupta, Sanjeev (Portland Press Ltd., 2012-08-01)The steroid hormone oestrogen is central to normal female physiology, reproduction and behaviour, through its effects on cellular processes including cell proliferation and cell survival. The effects of oestrogen are ... -
Prognostic significance of deregulated dicer expression in breast cancer
Caffrey, Emer; Ingoldsby, Helen; Wall, Deirdre; Webber, Mark; Dinneen, Kate; Murillo, Laura S.; Inderhaug, Celine; Newell, John; Gupta, Sanjeev; Callagy, Grace (Public Library of Science (PLoS), 2013-12-30)Background: Dicer, an RNase III-type endonuclease, is the key enzyme involved in RNA interference and microRNA pathways. Aberrant expression of Dicer is reported in several human cancers. Our aim was to assess the prognostic ... -
The prognostic value of protein and microRNA biomarkers in breast cancer and their role in tumour progression
Caffrey, Emer (2014-05-14)Identification of biomarkers has proven valuable in prognostication and treatment stratification of individual cases of breast cancer. microRNAs, short non-coding RNA molecules which negatively regulate translation of mRNA, ...