Browsing by Author "Abbah, Sunny A."
Now showing items 1-3 of 3
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Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture
Abbah, Sunny A.; Thomas, Dilip; Browne, Shane; O’Brien, Timothy; Pandit, Abhay; Zeugolis, Dimitrios I. (Springer Nature, 2016-02-10)Extracellular matrix synthesis and remodelling are driven by increased activity of transforming growth factor beta 1 (TGF-beta 1). In tendon tissue repair, increased activity of TGF-beta 1 leads to progressive fibrosis. ... -
Harnessing hierarchical nano- and micro-fabrication technologies for musculoskeletal tissue engineering
Abbah, Sunny A.; Delgado, Luis M.; Azeem, Ayesha; Fuller, Kieran; Shologu, Naledi; Keeney, Michael; Biggs, Manus J.; Pandit, Abhay; Zeugolis, Dimitrios I. (Wiley-Blackwell, 2015-11-01)Cells within a tissue are able to perceive, interpret and respond to the biophysical, biomechanical, and biochemical properties of the 3D extracellular matrix environment in which they reside. Such stimuli regulate cell ... -
Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury
Mohd Isa, Isma Liza; Abbah, Sunny A.; Kilcoyne, Michelle; Sakai, Daisuke; Dockery, Peter; Finn, David P.; Pandit, Abhay (American Association for the Advancement of Science (AAAS), 2018-04-01)Painful intervertebral disc degeneration is mediated by inflammation that modulates glycosylation and induces hyperinnervation and sensory sensitization, which result in discogenic pain. Hyaluronic acid (HA) used as a ...