Browsing by Subject "targeted disruption"
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The mrn complex: coordinating and mediating the response to broken chromosomes
(Wiley-Blackwell, 2003-09-01)The MRE11-RAD50-NBS1 (MRN) protein complex has been linked to many DNA metabolic events that involve DNA double-stranded breaks (DSBs). In vertebrate cells, all three components are encoded by essential genes, and hypomorphic ...