Browsing by Subject "prefrontal cortex"
Now showing items 1-10 of 10
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Antinociceptive effects of the GPR55 Antagonist CID16020046 injected into the rat anterior cingulate cortex
(Elsevier, 2020-07-13)The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, ... -
Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11c]nnc-112
(Springer Nature, 2008-10-22)The dopamine type-1 receptor has been implicated in major depressive disorder (MDD) by clinical and preclinical evidence from neuroimaging, post mortem, and behavioral studies. To date, however, selective in vivo assessment ... -
Effects of znf804a on auditory p300 response in schizophrenia
(Springer Nature, 2014-01-14)The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern ... -
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors
(Proceedings of the National Academy of Sciences, 2004-05-17)Mice unable to synthesize norepinephrine (NE) and epinephrine due to targeted disruption of the dopamine beta-hydroxylase gene, Dbh, were used to critically test roles for NE in mediating acute behavioral changes elicited ... -
The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
(Wiley, 2018-05-30)Background and Purpose The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ... -
Recurrent deletions of ulk4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility
(The Company of Biologists, 2013-11-27)Although many pathogenic copy number variations (CNVs) are associated with neuropsychiatric diseases, few of them have been functionally characterised. Here we report multiple schizophrenia cases with CNV abnormalities ... -
Stress, norepinephrine and depression
(Cambridge University Press (CUP), 2002-08-01)Experimental and clinical evidence implicates stress as a major predisposing factor in depression and other severe psychiatric disorders. In this review, evidence is presented to show how the impact of stress on the central ... -
Temporal relations and intelligence: correlating relational performance with performance on the wais-iii
(Springer Nature, 2008-10-01)Relational frame theory (RFT) explicitly suggests that derived relational responding underlies complex verbally-based cognitive performances. The current study investigated whether the ability to respond in accordance with ... -
The role of oxidative stress in methamphetamine-induced toxicity and sources of variation in the design of animal studies
(Bentham Science Publishers Ltd., 2017-01-04)Background: The prevalence of methamphetamine (MA) use has increased in recent years. In order to assess how this drug produces its effects, both clinical and preclinical studies have recently begun to focus on oxidative ...