Browsing by Subject "overexpression"
Now showing items 1-7 of 7
-
Aerosol-mediated delivery of aav2/6-iκbα attenuates lipopolysaccharide-induced acute lung injury in rats
(Mary Ann Liebert Inc, 2015-01-01)Inhibition of the proinflammatory transcription factor NF-kappa B has previously been shown to attenuate the inflammatory response in tissue after injury. However, the feasibility and efficacy of aerosolized adeno-associated ... -
Expression levels of her2/neu and those of collocated genes at 17q12-21, in breast cancer
(Spandidos Publications, 2012-04-23)HER2/neu is associated with poorer clinical outcome in breast cancer. Expression patterns of co-localised cancer-associated genes at 17q12-21 were examined using RT-PCR. The study group consisted of a 96-patient cohort. ... -
Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells
(Springer Nature, 2010-05-11)Background: Activator Protein-2 (AP-2) transcription factors are critically involved in a variety of fundamental cellular processes such as proliferation, differentiation and apoptosis and have also been implicated in ... -
Mir-379 regulates cyclin b1 expression and is decreased in breast cancer
(Public Library of Science (PLoS), 2013-07-10)MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ... -
Mnsod protects colorectal cancer cells from trail-induced apoptosis by inhibition of smac/diablo release
(Springer Nature, 2007-07-23)The mitochondrial enzyme manganese superoxide dismutase (MnSOD) has been shown to have two faces with regard to its role in tumor development. On the one side, it is well documented that overexpression of MnSOD slows down ... -
N-wasp is a novel regulator of hair-follicle cycling that controls antiproliferative tgf pathways
(The Company of Biologists, 2009-12-16)N-WASP is a cytoplasmic molecule mediating Arp2/3 nucleated actin polymerization. Mice with a keratinocyte-specific deletion of the gene encoding N-WASP showed normal interfollicular epidermis, but delayed hair-follicle ... -
Production of a recombinant swollenin from trichoderma harzianum in escherichia coli and its potential synergistic role in biomass degradation
(Springer Nature, 2017-05-16)Background: Fungal swollenins (SWOs) constitute a class of accessory proteins that are homologous to canonical plant expansins. Expansins and expansin-related proteins are well known for acting in the deagglomeration of ...