Browsing by Subject "microenvironment"
Now showing items 1-4 of 4
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Macromolecular crowding meets oxygen tension in human mesenchymal stem cell culture - a step closer to physiologically relevant in vitro organogenesis
(Springer Nature, 2016-08-01)Modular tissue engineering is based on the cells' innate ability to create bottom-up supramolecular assemblies with efficiency and efficacy still unmatched by man-made devices. Although the regenerative potential of such ... -
Multiple facets of the dna damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines
(Wiley-Blackwell, 2012-12-19)The regeneration of the hematopoietic system following total body irradiation is supported by host-derived mesenchymal stromal cells (MSCs) within the bone marrow. The mechanisms used by MSCs to survive radiation doses ... -
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix
(Springer Nature, 2017-03-27)The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell survival, proliferation, differentiation and metastasis. In multiple myeloma (MM), interactions ... -
Targeting the ep1 receptor reduces fas ligand expression and increases the antitumor immune response in anin vivomodel of colon cancer
(Wiley-Blackwell, 2013-03-04)Despite studies demonstrating that inhibition of cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) has significant chemotherapeutic benefits in vitro and in vivo, inhibition of COX enzymes is associated with serious ...