Browsing by Subject "functional-characterization"

Now showing items 1-6 of 6

    • Coordinated regulation of replication protein a activities by its subunits p14 and p32 

      Weisshart, Klaus; Pestryakov, Pavel; Smith, Richard W. P.; Hartmann, Hella; Kremmer, Elisabeth; Lavrik, Olga; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-06-17)
      The heterotrimeric replication protein A (RPA) has multiple essential activities in eukaryotic DNA metabolism and in signaling pathways. Despite extensive analyses, the functions of the smallest RPA subunit p14 are still ...

    • Dendritic cells facilitate accumulation of il-17t cells in the kidney following acute renal obstruction 

      Dong, Xiangyang; Bachman, Lori A.; Miller, Melinda N.; Nath, Karl A.; Griffin, Matthew D. (Elsevier BV, 2008-11-01)
      Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) ...

    • Human replication protein a 

      Pestryakov, Pavel E.; Weisshart, Klaus; Schlott, Bernhard; Khodyreva, Svetlana N.; Kremmer, Elisabeth; Grosse, Frank; Lavrik, Olga I.; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-02-24)
      Although the mechanical aspects of the single-stranded DNA (ssDNA) binding activity of human replication protein A (RPA) have been extensively studied, only limited information is available about its interaction with other ...

    • Initiation of jc virus dna replication in vitro by human and mouse dna polymerase alpha-primase 

      Smith, Richard W. P.; Nasheuer, Heinz-Peter (Wiley-Blackwell, 2003-05-01)
      Host species specificity of the polyomaviruses simian virus 40 (SV40) and mouse polyomavirus (PyV) has been shown to be determined by the host DNA polymerase alpha-primase complex involved in the initiation of both viral ...

    • Ionizing radiation-dependent and independent phosphorylation of the 32-kda subunit of replication protein a during mitosis 

      Stephan, Holger; Concannon, Claire; Kremmer, Elisabeth; Carty, Michael P.; Nasheuer, Heinz-Peter (Oxford University Press (OUP), 2009-08-11)
      The human single-stranded DNA-binding protein, replication protein A (RPA), is regulated by the N-terminal phosphorylation of its 32-kDa subunit, RPA2. RPA2 is hyperphosphorylated in response to various DNA-damaging agents ...

    • Production of a recombinant swollenin from trichoderma harzianum in escherichia coli and its potential synergistic role in biomass degradation 

      Santos, Clelton A.; Ferreira-Filho, Jaire A.; O’Donovan, Anthonia; Gupta, Vijai K.; Tuohy, Maria G.; Souza, Anete P. (Springer Nature, 2017-05-16)
      Background: Fungal swollenins (SWOs) constitute a class of accessory proteins that are homologous to canonical plant expansins. Expansins and expansin-related proteins are well known for acting in the deagglomeration of ...