Browsing by Subject "cytochrome-c release"
Now showing items 1-8 of 8
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Cytokine-induced β-cell apoptosis is no-dependent, mitochondria-mediated and inhibited by bcl-xl
(Wiley-Blackwell, 2008-04-01)Pro-inflammatory cytokines are implicated as the main mediators of beta-cell death during type 1 diabetes but the exact mechanisms remain unknown. This study examined the effects of interleukin-1 beta (IL-1 beta), ... -
Hspb1 facilitates erk-mediated phosphorylation and degradation of bim to attenuate endoplasmic reticulum stress-induced apoptosis
(Springer Nature, 2017-08-31)BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells ... -
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
(Springer Nature, 2014-05-01)Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ... -
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
(Wiley-Blackwell, 2008-07-10)Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell ... -
Photolon™ - photosensitization induces apoptosis via ros-mediated cross-talk between mitochondria and lysosomes
(Spandidos Publications, 2011-07-01)The localization of photosensitizers in the subcellular compartments during photodynamic therapy (PDT) plays a major role in the cell destruction; therefore, the aim of this study was to investigate the intracellular ... -
Regulation of apoptosis by heat shock proteins
(Wiley-Blackwell, 2014-05-01) -
Ripk1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved er stress conditions
(Springer Nature, 2014-12-04)Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and results in the activation of the unfolded protein response (UPR), which aims at restoring ER homeostasis. However, when the stress ... -
The mitochondrial death pathway: a promising therapeutic target in diseases
(Wiley-Blackwell, 2009-07-01)The mitochondrial pathway to apoptosis is a major pathway of physiological cell death in vertebrates. The mitochondrial cell death pathway commences when apoptogenic molecules present between the outer and inner mitochondrial ...