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    • Tdp2 protects transcription from abortive topoisomerase activity and is required for normal neural function 

      Gómez-Herreros, Fernando; Schuurs-Hoeijmakers, Janneke H M; McCormack, Mark; Greally, Marie T; Rulten, Stuart; Romero-Granados, Rocío; Counihan, Timothy J; Chaila, Elijah; Conroy, Judith; Ennis, Sean; Delanty, Norman; Cortés-Ledesma, Felipe; de Brouwer, Arjan P M; Cavalleri, Gianpiero L; El-Khamisy, Sherif F; de Vries, Bert B A; Caldecott, Keith W (Springer Nature, 2014-03-23)
      Topoisomerase II (TOP2) removes torsional stress from DNA and facilitates gene transcription by introducing transient DNA double-strand breaks (DSBs). Such DSBs are normally rejoined by TOP2 but on occasion can become ...