Browsing by Author "O’Malley, Ciaran"
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Crystal growth and design of multicomponent pharmaceuticals
O’Malley, Ciaran (NUI Galway, 2022-08-30)Cocrystallisation and salt formation is a widely studied method of optimising the action of Active Pharmaceutical Ingredients (APIs) without chemical modification of the parent compound. Careful selection of suitable ... -
Salts, binary and ternary cocrystals of pyrimethamine: mechanosynthesis, solution crystallization and crystallization from the gas phase
O’Malley, Ciaran; Bouchet, Chloe; Manyara, Grayce; Walsh, Niamh; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2020-11-24)A series of salts and binary and ternary cocrystals of the antimalaria drug pyrimethamine (PYR) are reported. PYR has a donor–acceptor–donor (DAD) and a donor–acceptor (DA) binding site, and cocrystallization experiments ... -
Use of sublimation catalysis and polycrystalline powder templates for polymorph control of gas phase crystallization
Kamali, Naghmeh; O’Malley, Ciaran; Mahon, Mary F.; Erxleben, Andrea; McArdle, Patrick (American Chemical Society, 2018-05-08)In pursuit of a solvent-free green alternative to solution-based processes, we have applied the combined use of catalytic additives and polycrystalline powder templates for polymorph control of gas phase crystallization ...