Browsing by Author "Liotta, Lance"
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High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer
Fitzgerald, Seán; Sheehan, Katherine M.; Espina, Virginia; O'Grady, Anthony; Cummins, Robert; Kenny, Dermot; Liotta, Lance; O'Kennedy, Richard; Kay, Elaine W.; Kijanka, Gregor S. (Wiley, 2014-11-13)Ceramide synthase 5 is involved in the de novo synthesis of ceramide, a sphingolipid involved in cell death and proliferation. In this study, we investigated the role of ceramide synthase 5 in colorectal cancer by examining ... -
Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
Fitzgerald, Seán; Espina, Virginia; Liotta, Lance; Sheehan, Katherine M.; O’Grady, Anthony; Cummins, Robert; O’Kennedy, Richard; Kay, Elaine W.; Kijanka, Gregor S. (BMC (part of Springer Nature), 2018-04-10)Background Stromal gene expression patterns predict patient outcomes in colorectal cancer. TRIM28 is a transcriptional co-repressor that regulates an abundance of genes through the KRAB domain family of transcription ...