Browsing by Author "Jansson, Ingela"
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Chemical selectivity of nucleobase adduction relative to in vivo mutation sites on exon 7 fragment of p53 tumor suppressor gene
Malla, Spundana; Kadimisetty, Karteek; Fu, You-Jun; Choudhary, Dharamainder; Jansson, Ingela; Schenkman, John B.; Rusling, James F. (Royal Society of Chemistry (RSC), 2015-01-01)Damage to p53tumor suppressor gene is found in half of all human cancers. Databases integrating studies of large numbers of tumors and cancer cell cultures show that mutation sites of specific p53 codons are correlated ... -
Elucidating organ-specific metabolic toxicity chemistry from electrochemiluminescent enzyme/dna arrays and bioreactor bead-lc-ms/ms
Wasalathanthri, Dhanuka P.; Li, Dandan; Song, Donghui; Zheng, Zhifang; Choudhary, Dharamainder; Jansson, Ingela; Lu, Xiuling; Schenkman, John B.; Rusling, James F. (Royal Society of Chemistry (RSC), 2015-01-01)Human toxic responses are very often related to metabolism. Liver metabolism is traditionally studied, but other organs also convert chemicals and drugs to reactive metabolites leading to toxicity. When DNA damage is found, ...