Browsing by Author "Gupta, A"
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Ncoa3 coactivator is a transcriptional target of xbp1 and regulates perk–eif2α–atf4 signalling in breast cancer
Gupta, A; Hossain, M M; Miller, N; Kerin, M; Callagy, G; Gupta, S (Springer Nature, 2016-04-25)XBP1 is a multitasking transcription factor and a key component of the unfolded protein response (UPR). Despite the wealth of knowledge about the role of XBP1 in luminal/ER-positive breast cancer, not much is known about ... -
Perk-dependent repression of mir-106b-25 cluster is required for er stress-induced apoptosis
Gupta, S; Read, D E; Deepti, A; Cawley, K; Gupta, A; Oommen, D; Verfaillie, T; Matus, S; Smith, M A; Mott, J L; Agostinis, P; Hetz, C; Samali, A (Springer Nature, 2012-06-01)Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be ...