Browsing by Author "Byrnes, Lucy"
Now showing items 1-10 of 10
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09-p080 effects of plakophilin 2 knockdown on zebrafish embryonic development
Moriarty, Miriam A.; Byrnes, Lucy; Grealy, Maura (Elsevier BV, 2009-08-01) -
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
Lynskey, Tracy (NUI Galway, 2018-12-14)Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ... -
Cloning of an atlantic salmon transcription factor
Stenson, Catherine; McNair, Alan; Byrnes, Lucy; Gannon, Frank (Portland Press Ltd., 1996-02-01) -
Desmosomal armadillo proteins in zebrafish cardiac development
Ryan, Rebecca (2012-12-18)Plakoglobin and plakophilin-2 are desmosomal armadillo proteins, required for correct cardiac development in zebrafish. Mutations in the human genes can cause the congenital heart defect arrhythmogenic right ventricular ... -
Insulin-like growth factor (igf) signalling is required for early dorso-anterior development of the zebrafish embryo
Eivers, Edward; Mccarthy, Karena; Glynn, Catherine; Nolan, Catherine M.; Byrnes, Lucy (UPV/EHU Press, 2004-01-01)The insulin-like growth factor (IGF) signalling pathway has been highly conserved in animal evolution and, in mammals and Xenopus, plays a key role in embryonic growth and development, with the IGF-1 receptor (IGF-1R) being ... -
Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos
Hartnett, Lori; Glynn, Catherine; Nolan, Catherine M.; Grealy, Maura; Byrnes, Lucy (UPV/EHU Press, 2010-01-01)The insulin-like growth factor (IGF) family is essential for normal embryonic growth and development and it is highly conserved through vertebrate evolution. However, the roles that the individual members of the IGF family ... -
Loss of plakophilin 2 disrupts heart development in zebrafish
Moriarty, Miriam A.; Ryan, Rebecca; Lalor, Pierce; Dockery, Peter; Byrnes, Lucy; Grealy, Maura (UPV/EHU Press, 2012-01-01)The desmosomal armadillo protein plakophilin 2 is the only plakophilin expressed in the heart, and mutations in the human plakophilin 2 gene result in arrhythmogenic right ventricular cardiomyopathy. To investigate loss ... -
Mouse induced pluripotent stem cells
Geoghegan, Eamon; Byrnes, Lucy (UPV/EHU Press, 2008-01-01)The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Kif4), represents ... -
Plakoglobin has both structural and signalling roles in zebrafish development
Martin, Eva D.; Moriarty, Miriam A.; Byrnes, Lucy; Grealy, Maura (Elsevier BV, 2009-03-01) -
Three-dimensional structure of a thermostable native cellobiohydrolase, cbh ib, and molecular characterization of the cel7 gene from the filamentous fungus, talaromyces emersonii
Grassick, Alice; Murray, Patrick G.; Thompson, Roisin; Collins, Catherine M.; Byrnes, Lucy; Birrane, Gabriel; Higgins, Timothy M.; Tuohy, Maria G. (Wiley-Blackwell, 2004-11-01)The X-ray structure of native cellobiohydrolase IB (CBH IB) from the filamentous fungus Talaromyces emersonii, PDB 1Q9H, was solved to 2.4 Angstrom by molecular replacement. 1Q9H is a glycoprotein that consists of a large, ...