Browsing by Title
Now showing items 4933-4952 of 14643
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Experimental and computational investigation into mechanobiology of osteocytes
(2014-10-31)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which comprise over 90% of the cells in mature bone tissue and are known to be highly sensitive to extracellular mechanical cues. The effect ... -
An experimental and computational investigation into procedural complications relating to transcatheter aortic heart valves
(NUI Galway, 2018-02-20)Although transcatheter aortic valves are widely used for treatment of high to medium risk patients with severe aortic stenosis, there are still many associated procedural complications. In particular, new on-set conductance ... -
Experimental and computational investigation of adhesion junction mechanosensation
(2017-02-28)Bone is an adaptive tissue that remodels in response to the mechanical loads placed upon it during normal daily activity. This remodelling process is vital to maintaining the mechanical integrity, mass and structure of ... -
Experimental and computational investigation of atherosclerotic plaque biomechanics
(NUI Galway, 2019-11-22)The overall objective of this thesis is to provide new insights into the composition and biomechanical behaviour of atherosclerotic plaque. Experimental and computational analysis techniques are developed to investigate ... -
Experimental and computational investigation of the active force generation of cells subjected to static and dynamic loading
(2016-05-13)The development of a mechanistic understanding of the processes by which cells sense and actively respond to the mechanical environment would represent a significant advance in the fields of biomechanics and tissue ... -
An experimental and computational investigation of the corrosion behaviour and mechanical performance of a bioabsorbable medical grade magnesium alloy
(NUI Galway, 2023-05-29)Magnesium-based medical implants have the potential to overcome several complications that arise with permanent metallic implants. Magnesium-based implants are biodegradable such that they can undergo absorption once ... -
An experimental and computational investigation of the high temperature behaviour of MarBN steel with application to effects of manufacturing
(NUI Galway, 2018-10-30)The key step for next generation power plants is the development of advanced materials capable of achieving high flexibility and efficiency at increased steam temperatures and pressures. Such operating conditions will cause ... -
Experimental and computational investigation of the impact of distorted stent expansion on the performance of transcatheter aortic valve replacements
(2014-12-22)Patients with calcific aortic valve stenosis present with calcium deposits on the aortic valve, which can result in non-circular and distorted expansion of self-expanding Transcatheter Aortic Valve Replacements. The effect ... -
An Experimental and Computational Investigation of the Inelastic Behaviour of Trabecular Bone
(2012-09-28)Achieving sufficient initial implant stability is of paramount importance for orthopaedic device longevity. In order to improve the design of orthopaedic devices it is essential to gain a better understanding of the ... -
An experimental and computational investigation of the mechanics of degradation in polymer bioresorbable scaffolds
(NUI Galway, 2023-10-03)Drug-eluting stents (DES) have established themselves as the gold-standard in treating arterial blockages, with over 1.3 million stent procedures carried out across Europe in coronary vessels alone. However, these permanent ... -
An experimental and computational investigation of the post-yield behaviour of trabecular bone during vertebral device subsidence
(Springer-Verlag, 2013)Interbody fusion device subsidence has been reported clinically. An enhanced understanding of the mechanical behaviour of the surrounding bone would allow for accurate predictions of vertebral subsidence. The multiaxial ... -
Experimental and computational investigation of the role of stress fiber contractility in the resistance of osteoblasts to compression
(2013)The mechanical behavior of the actin cytoskeleton has previously been investigated using both experimental and computational techniques. However, these investigations have not elucidated the role the cytoskeleton plays in ... -
An experimental and computational investigation on the biomechanics of polymer-covered self-expanding stents
(NUI Galway, 2021-07-09)Nitinol self-expanding stents are commonly used to treat peripheral artery disease. However, the femoropopliteal artery presents a challenging environment for stent placement, where large arterial deformations occur many ... -
An experimental and detailed kinetic modeling study of the pyrolysis and oxidation of allene and propyne over a wide range of conditions
(Elsevier, 2021-07-27)Allene and propyne are important intermediates in the pyrolysis and oxidation of higher hydrocarbon fuels, and they are also a major source of propargyl radical formation, which can recombine into different C 6 H 6 isomers ... -
Experimental and finite element investigations of the serviceability behaviour of CLT floors
(NUI Galway, 2020-02-06)Global environmental concerns with regard to sustaining our growing population is prompting the building community worldwide to increase urban density, while using optimised and sustainable resources. The traditional ... -
Experimental and kinetic modeling study of 2-methyl-2-butene: allylic hydrocarbon kinetics
(American Chemical Society, 2015-03-20)Two experimental studies have been carried out on the oxidation of 2-methyl-2-butene, one measuring ignition delay times behind reflected shock waves in a stainless steel shock tube, and the other measuring fuel, intermediate, ... -
Experimental and kinetic modeling study of 3-Methyl-2-butenol (Prenol) oxidation
(American Chemical Society, 2021-08-19)Longer chain alcohols with 4–5 carbon atoms are attractive alternative fuels as they can be derived from biological sources and since their combustion leads to lower exhaust gas levels of NOx and soot compared to commercial ... -
An experimental and kinetic modeling study of cyclopentane and dimethyl ether blends
(Elsevier, 2020-11-13)Cyclopentane is a suitable naphthene, or cycloalkane, in a palette for multi-component gasoline surro- gate fuels due to its presence in market fuels and its relevance to alkyl substituted cyclopentanes also present. ... -
An experimental and kinetic modeling study of n-hexane oxidation
(Elsevier, 2015-09-11)Ignition delay times for n-hexane oxidation have been measured in a rapid compression machine (RCM) at stoichiometric conditions and at 15 bar. Due to the high reactivity of n-hexane and non-ideal experimental effects ... -
An experimental and kinetic modeling study of the auto-ignition of natural gas blends containing C1–C7 alkanes
(Elsevier, 2020-07-16)Ignition delay time measurements for multi-component natural gas mixtures were carried out using a rapid compression machine at conditions relevant to gas turbine operation, at equivalence ratios of 0.5–2.0 in ‘air’ in the ...