Browsing University of Galway Support Services by Author "Newell, John"
Now showing items 1-20 of 35
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A cluster randomised controlled trial evaluating the effectiveness of a structured pulmonary rehabilitation education programme for improving the health status of people with chronic obstructive pulmonary disease (copd): the prince study protocol
Murphy, Kathy; Casey, Dympna; Devane, Declan; Cooney, Adeline; McCarthy, Bernard; Mee, Lorraine; Nichulain, Martina; Murphy, Andrew W; Newell, John; O' Shea, Eamon (Springer Nature, 2011-01-18)Background: A key strategy in improving care for people with chronic obstructive pulmonary disease (COPD) is the provision of pulmonary rehabilitation programmes. Pulmonary rehabilitation programmes have been successful ... -
A germline mutation in the brca13’utr predicts stage iv breast cancer
Dorairaj, Jemima J; Salzman, David W; Wall, Deirdre; Rounds, Tiffany; Preskill, Carina; Sullivan, Catherine AW; Lindner, Robert; Curran, Catherine; Lezon-Geyda, Kim; McVeigh, Terri; Harris, Lyndsay; Newell, John; Kerin, Michael J; Wood, Marie; Miller, Nicola; Weidhaas, Joanne B (Springer Nature, 2014-06-10)Background: A germline, variant in the BRCA1 3'UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. ... -
A randomised controlled trial of an exercise plus behaviour change intervention in people with multiple sclerosis: the step it up study protocol
Coote, Susan; Gallagher, Stephen; Msetfi, Rachel; Larkin, Aidan; Newell, John; Motl, Robert W; Hayes, Sara (Springer Nature, 2014-12-01)Background: Exercise has consistently yielded short-term, positive effects on health outcomes in people with multiple sclerosis (MS). However, these effects have not been maintained in the long-term. Behaviour change ... -
An evaluation of cro� myaction community lifestyle modification programme compared to standard care to reduce progression to diabetes/pre-diabetes in women with prior gestational diabetes mellitus (gdm): study protocol for a randomised controlled trial
Infanti, Jennifer J; Dunne, Fidelma P; O�Dea, Angela; Gillespie, Paddy; Gibson, Irene; Glynn, Liam G; Noctor, Eoin; Newell, John; McGuire, Brian E (Springer Nature, 2013-01-01)Background: Universal screening using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria has identified a prevalence of gestational diabetes mellitus (GDM) of 12.4% in women living in ... -
Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics
Kheirelseid, Elrasheid A. H.; Jumustafa, Hanzali; Miller, Nicola; Curran, Catherine; Sweeney, Karl; Malone, Carmel; McLaughlin, Ray; Newell, John; Kerin, Michael J. (Springer Nature, 2010-07-28)There has been conflicting evidence on the impact of bilateral breast cancer (BBC) on the survival and management of patients. The objectives of this study were to address the incidence of BBC and to investigate its ... -
Can the onset of type 2 diabetes be delayed by a group-based lifestyle intervention in women with prediabetes following gestational diabetes mellitus (gdm)? findings from a randomized control mixed methods trial
O’Dea, Angela; Tierney, Marie; McGuire, Brian E.; Newell, John; Glynn, Liam G.; Gibson, Irene; Noctor, Eoin; Danyliv, Andrii; Connolly, Susan B.; Dunne, Fidelma P. (Hindawi Limited, 2015-01-01)Objective. To evaluate a 12-week group-based lifestyle intervention programme for women with prediabetes following gestational diabetes (GDM). Design. A two-group, mixed methods randomized controlled trial in which 50 women ... -
Critical difference and biological variation in biomarkers of oxidative stress and nutritional status in athletes
Lewis, Nathan A.; Newell, John; Burden, Richard; Howatson, Glyn; Pedlar, Charles R. (Public Library of Science (PLoS), 2016-03-01)The longitudinal monitoring of oxidative stress (OS) in athletes may enable the identification of fatigued states and underperformance. The application of OS biomarker monitoring programs in sport are hindered by reliability ... -
Effect of exercising at minimum recommendations of the multiple sclerosis exercise guideline combined with structured education or attention control education – secondary results of the step it up randomised controlled trial
Coote, Susan; Uszynski, Marcin; Herring, Matthew P.; Hayes, Sara; Scarrott, Carl; Newell, John; Gallagher, Stephen; Larkin, Aidan; Motl, Robert W (Springer Nature, 2017-06-24)Background: Recent exercise guidelines for people with multiple sclerosis (MS) recommend a minimum of 30 min moderate intensity aerobic exercise and resistance exercise twice per week. This trial compared the secondary ... -
Effectiveness of a cognitive behavioural therapy-based rehabilitation programme (progressive goal attainment program) for patients who are work-disabled due to back pain: study protocol for a multicentre randomised controlled trial
Raftery, Miriam N; Murphy, Andrew W; O’Shea, Eamon; Newell, John; McGuire, Brian E (Springer Nature, 2013-01-01)Background: Psychologically informed rehabilitation programmes such as the Progressive Goal Attainment Program (PGAP) have the potential to address pain-related disability by targeting known psychological factors that ... -
Feasibility, acceptability and uptake rates of gestational diabetes mellitus screening in primary care vs secondary care: findings from a randomised controlled mixed methods trial
Tierney, Marie; O’Dea, Angela; Danyliv, Andriy; Glynn, Liam G.; McGuire, Brian E.; Carmody, Louise A; Newell, John; Dunne, Fidelma P. (Springer Nature, 2015-08-05)Aims/hypothesis It is postulated that uptake rates for gestational diabetes mellitus (GDM) screening would be improved if offered in a setting more accessible to the patient. The aim of this study was to evaluate the ... -
Group follow-up compared to individual clinic visits after structured education for type 1 diabetes: a cluster randomised controlled trial
Dinneen, Sean F.; O’Hara, Mary Clare; Byrne, Molly; Smith, Diarmuid; Courtney, Christopher H.; McGurk, Colm; Heller, Simon R.; Newell, John; Coffey, Norma; Breen, Cathy; O'Scannail, Mary; O'Shea, Donal (Elsevier BV, 2013-04-01) -
Identification of endogenous control genes for normalisation of real-time quantitative pcr data in colorectal cancer
Kheirelseid, Elrasheid AH; Chang, Kah; Newell, John; Kerin, Michael J; Miller, Nicola (Springer Nature, 2010-01-01)Background: Gene expression analysis has many applications in cancer diagnosis, prognosis and therapeutic care. Relative quantification is the most widely adopted approach whereby quantification of gene expression is ... -
Impact of tumour epithelial subtype on circulating micrornas in breast cancer patients
Waters, Peadar S.; Dwyer, Róisín M.; Brougham, Cathy; Glynn, Claire L.; Wall, Deirdre; Hyland, Peter; Duignan, Maria; McLoughlin, Mark; Newell, John; Kerin, Michael J. (Public Library of Science (PLoS), 2014-03-13)While a range of miRNAs have been shown to be dysregulated in the circulation of patients with breast cancer, little is known about the relationship between circulating levels and tumour characteristics. The aim of this ... -
Microrna-10a is reduced in breast cancer and regulated in part through retinoic acid
Khan, Sonja; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J; Dwyer, Róisín M. (Springer Nature, 2015-05-02)Background: MicroRNAs (miRNAs) are short non-coding RNA molecules that play a critical role in mRNA cleavage and translational repression, and are known to be altered in many diseases including breast cancer. MicroRNA-10a ... -
Mir-379 regulates cyclin b1 expression and is decreased in breast cancer
Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O’Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (Public Library of Science (PLoS), 2013-07-10)MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ... -
Multimorbidity and risk among patients with established cardiovascular disease: a cohort study
Glynn, Liam G; Buckley, Brian; Reddan, Donal; Newell, John; Hinde, John; Dinneen, Sean F; Murphy, Andrew W (Royal College of General Practitioners, 2008-07-01)Background Most patients managed in primary care have more than one condition. Multimorbidity presents challenges for the patient and the clinician, not only in terms of the process of care, but also in terms of management ... -
Preconditioning shields against vascular events in surgery (saves), a multicentre feasibility trial of preconditioning against adverse events in major vascular surgery: study protocol for a randomised control trial
Healy, Donagh; Clarke-Moloney, Mary; Gaughan, Brendan; O’Daly, Siobhan; Hausenloy, Derek; Sharif, Faisal; Newell, John; O’Donnell, Martin; Grace, Pierce; Forbes, John F; Cullen, Walter; Kavanagh, Eamon; Burke, Paul; Cross, Simon; Dowdall, Joseph; McMonagle, Morgan; Fulton, Greg; Manning, Brian J; Kheirelseid, Elrasheid AH; Leahy, Austin; Moneley, Daragh; Naughton, Peter; Boyle, Emily; McHugh, Seamus; Madhaven, Prakash; O’Neill, Sean; Martin, Zenia; Courtney, Donal; Tubassam, Muhammed; Sultan, Sherif; McCartan, Damian; Medani, Mekki; Walsh, Stewart (Springer Nature, 2015-04-23)Background: Patients undergoing vascular surgery procedures constitute a 'high-risk' group. Fatal and disabling perioperative complications are common. Complications arise via multiple aetiological pathways. This mechanistic ... -
Prognostic significance of deregulated dicer expression in breast cancer
Caffrey, Emer; Ingoldsby, Helen; Wall, Deirdre; Webber, Mark; Dinneen, Kate; Murillo, Laura S.; Inderhaug, Celine; Newell, John; Gupta, Sanjeev; Callagy, Grace (Public Library of Science (PLoS), 2013-12-30)Background: Dicer, an RNase III-type endonuclease, is the key enzyme involved in RNA interference and microRNA pathways. Aberrant expression of Dicer is reported in several human cancers. Our aim was to assess the prognostic ... -
Randomised controlled pilot trial of an exercise plus behaviour change intervention in people with multiple sclerosis: the step it up study
Hayes, Sara; Uszynski, Marcin Kacper; Motl, Robert W; Gallagher, Stephen; Larkin, Aidan; Newell, John; Scarrott, Carl; Coote, Susan (BMJ, 2017-10-01)Objective To investigate feasibility of multiple sclerosis (MS) exercise guidelines for inactive people with MS (PwMS) and to examine preliminary efficacy for walking. To investigate effect of augmenting that intervention ... -
Reasons for participation and non-participation in a diabetes prevention trial among women with prior gestational diabetes mellitus (gdm)
Infanti, Jennifer J; O’Dea, Angela; Gibson, Irene; McGuire, Brian E; Newell, John; Glynn, Liam G; O’Neill, Ciaran; Connolly, Susan B; Dunne, Fidelma P (Springer Nature, 2014-01-24)Background: Gestational diabetes mellitus (GDM) is a risk factor for the development of type 2 diabetes. Lifestyle intervention can prevent progression to type 2 diabetes in high risk populations. We designed a randomised ...