Browsing University of Galway Support Services by Author "Murphy, Paul"
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Cdc7-dependent and -independent phosphorylation of claspin in the induction of the dna replication checkpoint
Rainey, Michael; Harhen, Brendan; Wang, Guan-Nan; Murphy, Paul; Santocanale, Corrado (Informa UK Limited, 2013-05-15)Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can ... -
Lectins: getting familiar with translators of the sugar code
André, Sabine; Kaltner, Herbert; Manning, Joachim; Murphy, Paul; Gabius, Hans-Joachim (MDPI AG, 2015-01-22)The view on the significance of the presence of glycans in glycoconjugates is undergoing a paradigmatic change. Initially mostly considered to be rather inert and passive, the concept of the sugar code identifies glycans ... -
Methyl 2,3,6-tri-o-benzoyl-4-o-(tert-butyldimethylsilyl)-β-d-galactopyranoside
Bennett, Jack; Roux, Amélie; Murphy, Paul (MDPI AG, 2017-03-19)Methyl 2,3,6-tri-O-benzoyl-4-O-(tert-butyldimethylsilyl)-beta-D-galactopyranoside was synthesized in 47% yield by the silylation of a partially benzoylated galactose derivative, prepared from methyl beta-D-galactopyranoside. ... -
Multivalent carbohydrate-lectin interactions: how synthetic chemistry enables insights into nanometric recognition
Roy, René; Murphy, Paul; Gabius, Hans-Joachim (MDPI AG, 2016-05-13)Glycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell physiology. However, the factors explaining the exquisite selectivity of their functional pairing are not yet fully understood. ... -
Synthesis of a-o- and a-s-glycosphingolipids related to sphingomonous cell wall antigens using anomerisation
Pilgrim, Wayne; O'Reilly, Ciaran; Murphy, Paul (MDPI AG, 2013-09-12)Analogues of glycolipids from Spingomonadacaece with O- and S- and SO2-linkages have been prepared using chelation induced anomerisation promoted by TiCl4. Included are examples of the anomerisation of intermediates with ... -
The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity
Murphy, Paul; André, Sabine; Gabius, Hans-Joachim (MDPI AG, 2013-04-04)Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to ...