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Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate

ARAN - Access to Research at NUI Galway

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dc.contributor.author Rea, Kieran en
dc.contributor.author Roche, Michelle en
dc.contributor.author Finn, David P. en
dc.date.accessioned 2010-04-16T09:00:21Z en
dc.date.available 2010-04-16T09:00:21Z en
dc.date.issued 2007 en
dc.identifier.citation Rea K., Roche M. & Finn D.P. (2007). Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate. British Journal of Pharmacology, 152(5): 633-48. en
dc.identifier.uri http://hdl.handle.net/10379/838 en
dc.description.abstract Recent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of ¿-aminobutyric acid (GABA) and glutamate release. This article aims to review this evidence in the context of its implications for pain. We first provide a brief overview of supraspinal regulation of nociception, followed by a review of the evidence that the brain's endocannabinoid system modulates nociception. We look in detail at regulation of supraspinal GABAergic and glutamatergic neurons by the endocannabinoid system and by exogenously administered cannabinoids. Finally, we review the evidence that cannabinoid-mediated modulation of pain involves modulation of GABAergic and glutamatergic neurotransmission in key brain regions. en
dc.description.sponsorship SFI en
dc.format application/pdf en
dc.language.iso en en
dc.subject Pain en
dc.subject Brain en
dc.subject Cannabinoids en
dc.subject GABA en
dc.subject Glutamate en
dc.subject Neurotransmission en
dc.subject Nociception en
dc.subject Pharmacology & Therapeutics en
dc.title Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate en
dc.type Article en
dc.local.publishedsource http://dx.doi.org/10.1038/sj.bjp.0707440 en
dc.description.peer-reviewed peer-reviewed en

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