Browsing National Centre for Biomedical Engineering Science (Scholarly Articles) by Author "Cairns, Michael T."
Now showing items 1-14 of 14
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Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data
Talbot, Anita T.; Smith, Terry; Cairns, Michael T. (Elsevier, 2009-06-09)This study set out to investigate whether differential expression of genes for acute phase proteins in rainbow trout (Oncorhynchus mykiss) could be induced by confinement stress, a non-invasive method of activating the ... -
Analysis of stress-induced hepatic gene expression in rainbow trout (Oncorhynchus mykiss) selected for high- and low-responsiveness to stress
Pemmasani, Jhansi K.; Pottinger, Tom G.; Cairns, Michael T. (Elsevier, 2011-12)The production and welfare of intensively reared fish would be improved by reducing stress responsiveness. One approach to achieving this goal is selective breeding utilising stress-responsive genes as direct genetic markers ... -
Bovine kappa-casein gene promoter haplotypes with potential implications for milk protein expression
Keating, A. F.; Davoren, P.; Smith, T. J.; Cairns, Michael T. (Elsevier ScienceDirect, 2007-05-25)Genetic analysis of the kappa-casein gene (CSN3) promoter regions of 42 cattle representing 9 different breeds revealed that 2 distinct haplotypes (A and B) exist at this locus, differing from each other by single base ... -
A cDNA microarray assessment of gene expression in the liver of rainbow trout (Oncorhynchus mykiss) in response to a handling and confinement stressor
Cairns, Michael T.; Johnson, M. C.; Talbot, A. T.; Pernmasani, J. K.; McNeill, R. E.; Houeix, Benoit; Sangrador-Vegas, A.; Pottinger, T. G. (Elsevier, 2008-03)A purpose-designed microarray platform (Stressgenes, Phase 1) was utilised to investigate the changes in gene expression within the liver of rainbow trout during exposure to a prolonged period of confinement. Tissue and ... -
Characterisation of the differentially regulated trout protein 1 (DRTP1) gene in rainbow trout (Oncorhynchus mykiss)
Talbot, Anita T.; Smith, Terry; Cairns, Michael T. (Elsevier, 2008-10-04)Increased levels of differentially regulated trout protein 1 (DRTP1) mRNA transcripts have been reported in fish after activation of the acute phase response. While the function of the DRTP1 protein still remains to be ... -
Cloning and characterization of two genes encoding rainbow trout homologues of the IFITM protein family
Johnson, Mark C.; Sangrador-Vegas, Amaia; Smith, Terry; Cairns, Michael T. (Elsevier, 2006-04-15)To identify genes connected with leucocyte function in rainbow trout a cDNA library derived front head kidney leucocytes exposed to phytohemagglutinin (PHA) was screened. A clone with homology to the previously described ... -
Dietary vegetable oils do not alter the intestine transcriptome of gilthead sea bream (Sparus aurata), but modulate the transcriptomic response to infection with Enteromyxum leei
Cairns, Michael T.; Davey, Grace C. (BioMed Central, 2012)Background: Studies conducted with gilthead sea bream (Sparus aurata L.) have determined the maximum dietary replacement of fish meal and oil without compromising growth or product quality. The present study aimed to analyze ... -
Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
Chandran, Sreenath; Cairns, Michael T.; O'Brien, Margaret; O'Connell, Enda; Mashayekhi, Kaveh; Smith, Terry J. (American Physiological Society, 2016-01-01)A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that regulate ... -
Effects of combined progesterone and beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
Chandran, Sreenath; Cairns, Michael T.; O Brien, Margaret; O Connell, Enda; Mashayekhi, Kaveh; Smith, Terry (American Physiological Society, 2015)A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed in order to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that ... -
Isolation and characterization of the bovine Stearoyl-CoAdesaturase promoter and analysis of polymorphisms in the promoter region in dairy cows
Keating, Aileen F.; Murphy, John J.; Smith, Terry J.; Cairns, Michael T. (Springer, 2005-03)Conjugated linoleic acid (CLA) in milk arises through microbial biohydrogenation of dietary polyunsaturated fatty acids (PUFA) in the rumen, and by the action of mammary Stearoyl-CoA desaturase (Scd). A large variation ... -
A note on the evaluation of a beta-casein variant in bovine breeds by allele-specific PCR and relevance to beta-casomorphin
Keating, Aileen F.; Smith, Terry J.; Cairns, Michael T. (Teagasc; De Gruyter Open, 2008)Two genetic variants of the bovine beta-casein gene (A(1) and B) encode a histidine residue at codon 67, resulting in potential liberation of a bioactive peptide, beta-casomorphin, upon digestion. An allele-specific PCR ... -
A single nucleotide polymorphism in the bovine beta-casein promoter region across different bovine breeds
Keating, Aileen F.; Smith, Terry J.; Cairns, Michael T. (Cambridge Journals, 2006-02-14)The bovine β-casein (CSN2) gene has been shown to span a region of 8·5 kb, containing nine exons and eight intervening introns (Bonsing et al. 1988; Martin et al. 2002). The exons range in size from 24 to 498 bp; the ... -
Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar)
Guiry, Aoife; Flynn, Denis; Hubert, Sophie; O'Keeffe, Allan M; LeProvost, Olivier; White, Samantha L; Forde, Patrick F; Davoren, Pamela; Houeix, Benoit; Smith, Terry; Wilkins, Noel P.; Cairns, Michael T. (BioMed Central, 2010)Background: The male Atlantic salmon generally matures in fresh water upon returning after one or several years at sea. Some fast-growing male parr develop an alternative life strategy where they sexually mature before ... -
Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.)
Davey, Grace; Houeix, Benoit; Talbot, Anita; Cairns, Michael T. (BioMed Central, 2010-03-22)Background: Selection programs for growth and stress traits in cultured fish are fundamental to the improvement of aquaculture production. The gilthead sea bream ( Sparus aurata) is the main aquacultured species in the ...