Browsing National Centre for Biomedical Engineering Science (Scholarly Articles) by Author "|~|"
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Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data
Talbot, Anita T.; Smith, Terry; Cairns, Michael T. (Elsevier, 2009-06-09)This study set out to investigate whether differential expression of genes for acute phase proteins in rainbow trout (Oncorhynchus mykiss) could be induced by confinement stress, a non-invasive method of activating the ... -
Alignment-free clustering of transcription factor binding motifs using a genetic-k-medoids approach
Ó Broin, Pilib; Smith, Terry J.; Golden, Aaron (BioMed Central, 2015-01-28)Background: Familial binding profiles (FBPs) represent the average binding specificity for a group of structurally related DNA-binding proteins. The construction of such profiles allows the classification of novel motifs ... -
Analysis of stress-induced hepatic gene expression in rainbow trout (Oncorhynchus mykiss) selected for high- and low-responsiveness to stress
Pemmasani, Jhansi K.; Pottinger, Tom G.; Cairns, Michael T. (Elsevier, 2011-12)The production and welfare of intensively reared fish would be improved by reducing stress responsiveness. One approach to achieving this goal is selective breeding utilising stress-responsive genes as direct genetic markers ... -
Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells
Chris Linehan, Sanjeev Gupta, Afshin Samali, Lynn O Connor (2012) -
Bovine kappa-casein gene promoter haplotypes with potential implications for milk protein expression
Keating, A. F.; Davoren, P.; Smith, T. J.; Cairns, Michael T. (Elsevier ScienceDirect, 2007-05-25)Genetic analysis of the kappa-casein gene (CSN3) promoter regions of 42 cattle representing 9 different breeds revealed that 2 distinct haplotypes (A and B) exist at this locus, differing from each other by single base ... -
A cDNA microarray assessment of gene expression in the liver of rainbow trout (Oncorhynchus mykiss) in response to a handling and confinement stressor
Cairns, Michael T.; Johnson, M. C.; Talbot, A. T.; Pernmasani, J. K.; McNeill, R. E.; Houeix, Benoit; Sangrador-Vegas, A.; Pottinger, T. G. (Elsevier, 2008-03)A purpose-designed microarray platform (Stressgenes, Phase 1) was utilised to investigate the changes in gene expression within the liver of rainbow trout during exposure to a prolonged period of confinement. Tissue and ... -
Characterisation of the differentially regulated trout protein 1 (DRTP1) gene in rainbow trout (Oncorhynchus mykiss)
Talbot, Anita T.; Smith, Terry; Cairns, Michael T. (Elsevier, 2008-10-04)Increased levels of differentially regulated trout protein 1 (DRTP1) mRNA transcripts have been reported in fish after activation of the acute phase response. While the function of the DRTP1 protein still remains to be ... -
Cloning and characterization of two genes encoding rainbow trout homologues of the IFITM protein family
Johnson, Mark C.; Sangrador-Vegas, Amaia; Smith, Terry; Cairns, Michael T. (Elsevier, 2006-04-15)To identify genes connected with leucocyte function in rainbow trout a cDNA library derived front head kidney leucocytes exposed to phytohemagglutinin (PHA) was screened. A clone with homology to the previously described ... -
Construction of a Natural Mucin Microarray and Interrogation for Biologically Relevant Glyco-Epitopes
Kilcoyne, Michelle; Gerlach, Jared Q.; Kane, Marian; Joshi, Lokesh (2012)Mucins are the principal components of mucus, and mucin glycosylation has important roles in defense, microbial adhesion, immunomodulation, inflammation, and cancer. Mucin expression and glycosylation are dynamic, responding ... -
Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy
Smith, Terry (2013)Background: Obesity is becoming an increasing problem in obstetric practice; it has led to an increase in the risk of caesarean delivery, prolonged pregnancy and dysfunctional labour. It has been postulated that many of ... -
Dependence of mechanical properties of polyamide components on build parameters in the SLS process
Lohfeld, Stefan; McHugh, Peter E.; Caulfield, Brian (Elsevier, 2007)Customised properties of parts manufactured using the selective laser sintering process are achievable by variation of build parameters. The energy density, controlled by laser power, distance between scan lines and speed ... -
Development of a rapid recombinase polymerase amplification assay for the detection of Streptococcus pneumoniae in whole blood
Clancy, Eoin; Higgins, Owen; Boo, Teck Wee; Cormican, Martin; Barry, Thomas; Smith, Terry J. (BioMed Central, 2015-10-29)Background: Streptococcus pneumoniae is an important cause of microbial disease in humans. The introduction of multivalent vaccines has coincided with a dramatic decrease in the number of pneumococcal-related deaths. In ... -
Dietary vegetable oils do not alter the intestine transcriptome of gilthead sea bream (Sparus aurata), but modulate the transcriptomic response to infection with Enteromyxum leei
Cairns, Michael T.; Davey, Grace C. (BioMed Central, 2012)Background: Studies conducted with gilthead sea bream (Sparus aurata L.) have determined the maximum dietary replacement of fish meal and oil without compromising growth or product quality. The present study aimed to analyze ... -
Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion
Samali, Afshin (2013)Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ... -
Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
Chandran, Sreenath; Cairns, Michael T.; O'Brien, Margaret; O'Connell, Enda; Mashayekhi, Kaveh; Smith, Terry J. (American Physiological Society, 2016-01-01)A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that regulate ... -
Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells
Prasad, Babu R.; Mullins, Gillian; Nikolskaya, Natalia; Connolly, David; Smith, Terry; Rochev, Yury (BioMed Central, 2012-01-20)Background: The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid ... -
Engineering assisted surgery: A route for digital design and manufacturing of customized maxillofacial implants
Serban, D.; Boyle, D.; O'Donnell, G.; Lohfeld, Stefan; McHugh, Peter E.; Peckitt, Ninian (Elsevier, 2007)Rapid prototyping (RP) and more recently rapid manufacturing (RM) as a part of Engineering Assisted Surgery enables manufacturing of customised implants and prostheses prior to surgical procedures. Beginning with CT ... -
Evaluation of a novel PCR based diagnostic assay for the detection of Mycobacterium tuberculosis in sputum specimens
Maher, Majella; Glennon, Maura; Smith, Terry; Dawson, Michael T. (ACM, 1996-06-18)We report on a PCR-based assay we have developed for the detection of Mycobacterium tuberculosis in sputum samples. One hundred sputum specimens, which included 34 culture-positive and 66 culture-negative specimens, were ... -
Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs.
Wernecke, Martina; Mullen, Ciara; Sharma, Vimla; Morrison, John; Barry, Thomas; Maher, Majella; Smith, Terry (2009)Despite the implementation of prevention guidelines, early-onset group B streptococci (GBS) disease remains a cause of neonatal morbidity and mortality worldwide. Strategies to identify women who are at risk of transmitting ... -
Finite element predictions compared to experimental results for the effective modulus of bone tissue engineering scaffolds fabricated by selective laser sintering
Lohfeld, Stefan; McHugh, Peter E.; Cahill, Senan (Springer Verlag, 2009)A current challenge in bone tissue engineering is to create scaffolds with suitable mechanical properties, high porosity, full interconnectivity and suitable pore size. In this paper, polyamide and polycaprolactone scaffolds ...