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Stress-induced analgesia.

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dc.contributor.author Butler, Ryan K. en
dc.contributor.author Finn, David P. en
dc.date.accessioned 2010-03-12T12:59:15Z en
dc.date.available 2010-03-12T12:59:15Z en
dc.date.issued 2009 en
dc.identifier.uri http://hdl.handle.net/10379/761 en
dc.description.abstract For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, ¿-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders. en
dc.description.sponsorship SFI en
dc.format application/pdf en
dc.language.iso en en
dc.publisher Butler, R. K. & Finn, D.P. (2009). Stress-induced analgesia. Progress in Neurobiology, 88, 184-202. en
dc.subject Pain en
dc.subject Stress-induced analgesia en
dc.subject Fear en
dc.subject Rodent en
dc.subject Human en
dc.subject.lcsh Pain treatment en
dc.subject.lcsh Analgesia en
dc.subject.lcsh Analgesia en
dc.title Stress-induced analgesia. en
dc.type Article en
dc.local.publishedsource http://dx.doi.org/10.1016/j.pneurobio.2009.04.003 en
dc.description.peer-reviewed peer-reviewed en

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