dc.contributor.author | Butler, Ryan K. | en |
dc.contributor.author | Finn, David P. | en |
dc.date.accessioned | 2010-03-12T12:59:15Z | en |
dc.date.available | 2010-03-12T12:59:15Z | en |
dc.date.issued | 2009 | en |
dc.identifier.uri | http://hdl.handle.net/10379/761 | en |
dc.description.abstract | For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, ¿-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders. | en |
dc.description.sponsorship | SFI | en |
dc.format | application/pdf | en |
dc.language.iso | en | en |
dc.publisher | Butler, R. K. & Finn, D.P. (2009). Stress-induced analgesia. Progress in Neurobiology, 88, 184-202. | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Pain | en |
dc.subject | Stress-induced analgesia | en |
dc.subject | Fear | en |
dc.subject | Rodent | en |
dc.subject | Human | en |
dc.subject.lcsh | Pain treatment | en |
dc.subject.lcsh | Analgesia | en |
dc.subject.lcsh | Analgesia | en |
dc.title | Stress-induced analgesia. | en |
dc.type | Article | en |
dc.local.publishedsource | http://dx.doi.org/10.1016/j.pneurobio.2009.04.003 | en |
dc.description.peer-reviewed | peer-reviewed | en |
nui.item.downloads | 4872 | |