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Stress-induced analgesia.

ARAN - Access to Research at NUI Galway

Show simple item record Butler, Ryan K. en Finn, David P. en 2010-03-12T12:59:15Z en 2010-03-12T12:59:15Z en 2009 en
dc.identifier.uri en
dc.description.abstract For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, ¿-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders. en
dc.description.sponsorship SFI en
dc.format application/pdf en
dc.language.iso en en
dc.publisher Butler, R. K. & Finn, D.P. (2009). Stress-induced analgesia. Progress in Neurobiology, 88, 184-202. en
dc.subject Pain en
dc.subject Stress-induced analgesia en
dc.subject Fear en
dc.subject Rodent en
dc.subject Human en
dc.subject.lcsh Pain treatment en
dc.subject.lcsh Analgesia en
dc.subject.lcsh Analgesia en
dc.title Stress-induced analgesia. en
dc.type Article en
dc.local.publishedsource en
dc.description.peer-reviewed peer-reviewed en

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