Browsing School of Physics by Author "Leahy, Martin"
Now showing items 1-17 of 17
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Accessing depth-resolved high spatial frequency content from the optical coherence tomography signal
Alexandrov, Sergey; Arangath, Anand; Zhou, Yi; Murphy, Mary; Duffy, Niamh; Neuhaus, Kai; Shaw, Georgina; McAuley, Ryan; Leahy, Martin (Nature Research, 2021-08-24)Optical coherence tomography (OCT) is a rapidly evolving technology with a broad range of applications, including biomedical imaging and diagnosis. Conventional intensity-based OCT provides depth-resolved imaging with a ... -
Characterization of an amplified piezoelectric actuator for multiple reference optical coherence tomography
O'Gorman, Sean; Neuhaus, Kai; Alexandrov, Sergey; Hogan, Josh; Wilson, Carol; McNamara, Paul M.; Leahy, Martin (Optica, 2018-08-30)The characterization of an amplified piezoelectric actuator (APA) as a new axial scanning method for multiple-reference optical coherence tomography (MR-OCT) is described. MR-OCT is a compact optical imaging device based ... -
Characterization of nanosensitive multifractality in submicron scale tissue morphology and its alteration in tumor progression
Das, Nandan; Alexandrov, Sergey; Gilligan, Katie E.; Dwyer, Róisín M.; Saager, Rolf B.; Ghosh, Nirmalya; Leahy, Martin (Society of Photo-optical Instrumentation Engineers, 2021-01-11)Significance: Assessment of disease using optical coherence tomography is an actively investigated problem, owing to many unresolved challenges in early disease detection, diagnosis, and treatment response monitoring. The ... -
Functional imaging for regenerative medicine
Leahy, Martin; Thompson, Kerry; Zafar, Haroon; Alexandrov, Sergey; Foley, Mark; O’Flatharta, Cathal; Dockery, Peter (BMC, 2016-04-19)In vivo imaging is a platform technology with the power to put function in its natural structural context. With the drive to translate stem cell therapies into pre-clinical and clinical trials, early selection of the right ... -
In vivo correlation mapping microscopy
McGrath, James; Alexandrov, Sergey; Owens, Peter; Subhash, Hrebesh; Leahy, Martin (Society of Photo-optical Instrumentation Engineers (SPIE), 2016-03)To facilitate regular assessment of the microcirculation in vivo, noninvasive imaging techniques such as nailfold capillaroscopy are required in clinics. Recently, a correlation mapping technique has been applied to optical ... -
Label free ultra-sensitive imaging with sub-diffraction spatial resolution
Alexandrov, Sergey; Das, Nandan; McGrath, James; Owens, Peter; Sheppard, Colin J. R.; Boccafoschi, Francesca; Giannini, Cinzia; Sibillano, Teresa; Subhash, Hrebesh; Leahy, Martin (IEEE, 2019-07-09)In this paper, we show a new way to break the resolution limit and dramatically improve sensitivity to structural changes. To realize it we developed a novel label free contrast mechanism, based on the spectral encoding ... -
Label-free ultra-sensitive visualization of structure below the diffraction resolution limit
Alexandrov, Sergey; McGrath, James; Sheppard, Colin J. R.; Boccafoschi, Francesca; Giannini, Cinzia; Sibillano, Teresa; Subhash, Hrebesh; Hogan, Josh; Leahy, Martin (Wiley, 2018-03-23)For both fundamental study of biological processes and early diagnosis of diseases, information about nanoscale changes in tissue and cell structure is crucial. Nowadays, almost all currently known nanoscopy methods rely ... -
Microcirculation imaging based on full-range high-speed spectral domain correlation mapping optical coherence tomography
Subhash, Hrebesh M.; Leahy, Martin (SPIE (International Society for Optics and Photonics, 2014)Microcirculation imaging is a key parameter for studying the pathophysiological processes of various disease conditions, in both clinical and fundamental research. A full-range spectral-domain correlation mapping optical ... -
Nano-sensitive optical coherence tomography
Alexandrov, Sergey; Subhash, Hrebesh M.; Zam, Azhar; Leahy, Martin (Royal Society of Chemistry, 2014)Depth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and ... -
Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography
Das, Nandan; Sergey, Alexandrov; Zhou, Yi; Gilligan, Katie E.; Dwyer, Róisín M.; Leahy, Martin (Royal Society of Chemistry, 2020-05-25)Approximately 90% of cancers originate in epithelial tissues leading to epithelial thickening, but the ultrastructural changes and underlying architecture are less well known. Depth resolved label free visualization of ... -
Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures
Subhash, Hrebesh M.; Leahy, Martin; Alexandrov, Sergey (IOP Science, 2014-03-06)We briefly discuss the principle of image formation in Fourier domain optical coherence tomography (OCT). The theory of a new approach to improve dramatically the sensitivity of conventional OCT is described. The approach ... -
Nanosensitive optical coherence tomography to assess wound healing within the cornea
Lal, Cerine; Alexandrov, Sergey; Rani, Sweta; Zhou, Yi; Ritter, Thomas; Leahy, Martin (Optical Society of America, 2020-05-01)Optical coherence tomography (OCT) is a non-invasive depth resolved optical imaging modality, that enables high resolution, cross-sectional imaging in biological tissues and materials at clinically relevant depths. Though ... -
Noninvasive detection of nanoscale structural changes in cornea associated with cross-linking treatment
Zhou, Yi; Alexandrov, Sergey; Nolan, Andrew; Das, Nandan; Dey, Rajib; Leahy, Martin (Wiley, 2020-02-17)Corneal cross-linking (CXL) using ultraviolet-A (UVA) irradiation with a riboflavin photosensitizer has grown from an interesting concept to a practical clinical treatment for corneal ectatic diseases globally, such as ... -
Novel approach for label free super-resolution imaging in far field
Alexandrov, Sergey; McGrath, James; Hrebesh, Subhash; Leahy, Martin (Nature Publishing Group, 2015)Progress in the emerging areas of science and technology, such as bio- and nano-technologies, depends on development of corresponding techniques for imaging and probing the structures with high resolution. Recently, the ... -
Simple characterization scheme for optical coherence tomography systems with application to a commercial and a near-isometric resolution fibre-based system
Dey, Rajib; Zhou, Yi; Neuhaus, Kai; Alexandrov, Sergey; Nolan, Andrew; Chang, Ting-Chiao; Leahy, Martin (2021-12-14)Optical Coherence Tomography (OCT) is a rapidly growing imaging modality in biomedical optics. OCT can perform high-resolution, cross-sectional imaging of the microstructure of biological tissues by measuring the coherent ... -
Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization
Alexandrov, Sergey; McNamara, Paul M.; Das, Nandan; Zhou, Yi; Lynch, Gillian; Hogan, Josh; Leahy, Martin (AIP Publishing, 2019-09-16)Most of the fundamental pathological processes in living tissues exhibit changes at the nanoscale. Noninvasive, label-free detection of structural changes in biological samples pose a significant challenge to both researchers ... -
Tissue viability imaging of skin microcirculation following exposure to Cold Air (-110°C) and Cold Water (8°C)
Leahy, Martin (CIAFEL, 2013)Cryotherapy is currently used in various clinical, rehabilitative and sporting settings. However, very little is known regarding the impact of cooling on the microcirculatory response. Objectives: The present study sought ...