Browsing Pharmacology & Therapeutics by Author "http://dx.doi.org/10.13039/501100001602"
Now showing items 1-20 of 25
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Alterations in the central opioid system following acute swim stress and olfactory bulbectomy in the rat
McHugh, K.; P.Calcagno, P.; Calcagno, P.; Ferdousi, M.; Sanchez, C.; Roche, Michelle; Finn, David P.; Kelly, John P. (Elsevier, 2019-12-13)Introduction: Stress is a major component of many animal models of depression, induced acutely as in the forced swim test, or more long-term in the olfactory bulbectomy (OB) and chronic mild stress models [1]. The central ... -
Antinociceptive effects of the GPR55 Antagonist CID16020046 injected into the rat anterior cingulate cortex
Okine, Bright N.; Mc Laughlin, Gemma; Gaspar, Jessica C.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Elsevier, 2020-07-13)The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, ... -
Attenuation of fear‐conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB2 receptors
Corcoran, Louise; Mattimoe, Darragh; Roche, Michelle; Finn, David P. (The British Pharmacological Society, 2020-01-22)Improved understanding of brain mechanisms regulating endogenous analgesia is important from a fundamental physiological perspective and for identification of novel therapeutic strategies for pain. The endocannabinoid ... -
Brain repair for Parkinson's disease: is the answer in the matrix?
Moriarty, Niamh; Dowd, Eilís (Medknow Publications, 2018-07-13)Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name, there is still an irrefutable need for a therapy that targets the underlying pathophysiology ... -
Cannabinoids and pain: sites and mechanisms of action
Starowicz, Katarzyna; Finn, David P. (Elsevier, 2017-06-20)The endocannabinoid system, consisting of the cannabinoid(1) receptor (CB1R) and cannabinoid(2) receptor (CB2R), endogenous cannabinoid ligands (endocannabinoids), and metabolizing enzymes, is present throughout the pain ... -
Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia
Okine, Bright N.; Gaspar, Jessica C.; Madasu, Manish K.; Olango, Weredeselam M.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Elsevier, 2016-12-01)The stress-hyperresponsive Wistar-Kyoto (WRY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling ... -
Cognition and pain
Moriarty, Orla; Finn, David P. (Lippincott, Williams & Wilkins, 2014-06)Purpose of reviewPain and cognition share common neural substrates and are known to interact reciprocally. This has implications for treatment and management of pain conditions; pain can negatively affect cognitive ... -
Differential role of anterior cingulate cortical glutamatergic neurons in pain-related aversion learning and nociceptive behaviors in male and female rats
Jarrin, Sarah; Pandit, Abhay; Roche, Michelle; Finn, David P. (Frontiers Media, 2020-08-11)Pain is comprised of both sensory and affective components. The anterior cingulate cortex (ACC) is a key brain region involved in the emotional processing of pain. Specifically, glutamatergic transmission within the ACC ... -
Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: Opioid receptor dependency and molecular correlates
Butler, Ryan K.; Rea, Kieran; Lang, Yvonne; Gavin, Aisling M.; Finn, David P. (International Association for the Study of Pain, 2008-12)The opioid and endocannabinoid systems mediate analgesia expressed upon re-exposure to a contextually aversive stimulus (fear-conditioned analgesia; FCA), and modulate the mitogen-activated protein kinase (MAPK) pathway. ... -
Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey
Madasu, Manish K.; Okine, Bright N.; Olango, Weredeselam M.; Rea, Kieran; Lenihan, Róisín; Roche, Michelle; Finn, David P. (Elsevier, 2016-08-09)Negative affective state has a significant impact on pain, and genetic background is an important moderating influence on this interaction. The Wistar-Kyoto (WKY) inbred rat strain exhibits a stress-hyperresponsive, ... -
Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state.
Ferdousi, Mehnaz I.; Calcagno, Patricia; Clarke, Morgane; Aggarwal, Sonali; Sanchez, Connie; Smith, Karen L.; Eyerman, David J.; Kelly, John P.; Roche, Michelle; Finn, David P. (Lippincott, Williams & Wilkins, 2020-08-17)Chronic pain is often comorbid with anxiety and depression, altering the level of perceived pain, which negatively affects therapeutic outcomes. The role of the endogenous mu-opioid receptor (MOP) system in pain-negative ... -
Impaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathy
Moriarty, Orla; Lang, Yvonne; Idrees, Zubair; McGuire, Brian E.; Finn, David P. (Elsevier, 2016-01-13)Diabetes, and associated diabetic neuropathic pain, impact negatively on cognitive function. However, the underlying mechanisms remain poorly understood. This study investigated neuropathic pain-related behaviour and ... -
Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli
Rea, Kieran; Olango, Weredeselam M.; Okine, Bright N.; Madasu, Manish K.; McGuire, Iseult C.; Coyle, Kathleen; Harhen, Brendan; Roche, Michelle; Finn, David P. (International Association for the Study of Pain, 2014-01)Pain is both a sensory and an emotional experience, and is subject to modulation by a number of factors including genetic background modulating stress/affect. The Wistar-Kyoto (WKY) rat exhibits a stress-hyper-responsive ... -
Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats
Ford, Gemma K.; Moriarty, Orla; Okine, Bright N.; Tully, E.; Mulcahy, A.; Harhen, Brendan; Finn, David P. (Wiley, 2014-11-15)BackgroundDistraction is used clinically to relieve and manage pain. It is hypothesized that pain demands attention and that exposure to another attention-demanding stimulus causes withdrawal of attention away from painful ... -
Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats
Burke, Nikita N.; Ferdousi, Mehnaz; Deaver, Daniel R.; Finn, David P.; Roche, Michelle; Kelly, John P. (Elsevier, 2018-12-13)Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial mu-opioid receptor (MOR) agonist and ... -
Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders
Smith, Karen L.; Jessop, David S.; Finn, David P. (Taylor & Francis, 2009-07-07)In this review, we present evidence for the involvement of imidazoline binding sites (IBS) in modulating responses to stress, through central control of monoaminergic and hypothalamo-pituitary-adrenal (HPA) axis activity. ... -
N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism
Okine, Bright N.; Madasu, Manish K.; McGowan, Fiona; Prendergast, Charles; Gaspar, Jessica C.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Lippincott, Williams & Wilkins, 2016-12)The neural substrates and mechanisms mediating the antinociceptive effects of the endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation. We investigated the effects of exogenous PEA ... -
Pharmacological blockade of PPAR isoforms increases conditioned fear responding in the presence of nociceptive tone
Gaspar, Jessica C.; Okine, Bright N.; Llorente-Berzal, Alvaro; Roche, Michelle; Finn, David P. (MDPI, 2020-02-24)Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPAR¿, PPARß/¿, PPAR¿) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pain-fear ... -
PPARs and pain
Okine, Bright N.; Gaspar, Jessica C.; Finn, David P. (Wiley, 2018-04-21)Chronic pain is a common cause of disability worldwide and remains a global health and socio-economic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain or ... -
The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
Rea, Kieran; McGowan, Fiona; Corcoran, Louise; Roche, Michelle; Finn, David P. (Wiley, 2018-05-30)Background and Purpose The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ...