Browsing School of Medicine by Author "Ford, Gemma K."
Now showing items 1-8 of 8
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Behavioural, neurochemical and neuroendocrine effects of the endogenous beta-carboline harmane in fear-conditioned rats
Smith, Karen L.; Ford, Gemma K.; Finn, David P. (2012)The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the ... -
Clinical correlates of stress-induced analgesia: evidence from pharmacological studies
Ford, Gemma K.; Finn, David P. (Elsevier, 2008) -
The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nocicpetive tone
Olango, W.M.; Roche, Michelle; Ford, Gemma K.; Harhen, Brendan; Finn, David P. (Wiley, 2011)Background and purpose: Endocannabinoids in the midbrain periaqueductal grey (PAG) are involved in modulating nociception and unconditioned stress-induced analgesia, however, their role in fear-conditioned analgesia (FCA) ... -
Fear-induced suppression of nociceptive behaviour and activation of signal transduction molecules in the rat periaqueductal grey: role of fatty acid amide hydrolase.
Butler, Ryan K.; Ford, Gemma K.; Hogan, Michelle; Roche, Michelle; Doyle, Karen M.; Kelly, John P.; Finn, David P. (Sage, 2011-09-17)The endocannabinoid system regulates nociception and aversion and mediates fear-conditioned analgesia (FCA). We investigated the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which inhibits the catabolism ... -
Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain
Moriarty, Orla; Gorman, Claire L.; McGowan, Fiona; Ford, Gemma K.; Roche, Michelle; Thompson, Kerry; Dockery, Peter; McGuire, Brian E.; Finn, David P. (De Gruyter, 2016-01-01)Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural mechanisms involved are poorly understood. Chronic pain is associated with changes in synaptic plasticity in the brain which ... -
Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats
Ford, Gemma K.; Moriarty, Orla; Okine, Bright N.; Tully, E.; Mulcahy, A.; Harhen, Brendan; Finn, David P. (Wiley, 2014-11-15)BackgroundDistraction is used clinically to relieve and manage pain. It is hypothesized that pain demands attention and that exposure to another attention-demanding stimulus causes withdrawal of attention away from painful ... -
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor
Kerr, D.M.; Burke, N.N.; Ford, Gemma K.; Harhen, Brendan; Egan, Laurence J.; Finn, David P.; Roche, Michelle (Elsevier, 2011-09)The endocannabinoid system is an important regulator of the nervous, neuroendocrine, and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, ... -
A role for the ventral hippocampal endocannabinoid system in fear-conditioned analgesia and fear responding in the presence of nociceptive tone in rats.
Ford, Gemma K.; Kieran, Siobhan; Dolan, Kenneth; Harhen, Brendan; Finn, David P. (Elsevier, 2011-08)The endogenous cannabinoid (endocannabinoid) system plays an important role in fear-conditioned analgesia (FCA) and expression and extinction of conditioned fear. The hippocampus has an established role in both pain and ...