Browsing School of Medicine by Author "|~|"
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11q13 is a susceptibility locus for hormone receptor positive breast cancer.
Kerin, Michael J.; Miller, Nicola (Wiley, 2012-07)A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these ... -
The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy
Cannon, Dara (2013)Objective: To study 5-HT transport and 5-HT1A receptors in temporal lobe epilepsy (TLE) and depression.Methods: Thirteen patients had PET with [C-11]DASB for 5-HTT and [F-18]FCWAY for 5-HT1A receptor binding, MRI, and ... -
6-iodonordihydrocapsaicin
Roche, Michelle; Finn, David P. (2009)6-Iodonordihydrocapsaicin was first synthesized by Giovanni Appendino at the Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences (DiSCAFF), Novara, Italy, while developing a series of halogenated ... -
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
Burke, Nikita N.; Geoghegan, E.; Moriarty, Orla; Finn, David P.; Kerr, Daniel M.; Roche, Michelle (Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Anandamide modulation of endotoxin-induced inflammation
Kerr, Daniel M.; Henry, Rebecca; Roche, Michelle (OMICS International, 2013-12-20)The endocannabinoid system is comprised of the CB1 and CB2 receptors, the naturally occurring endogenous ligands, anandamide (AEA) and 2-arachidonyl glycerol (2-AG); and the enzymes involved in their synthesis and ... -
Antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in Ireland
Vellinga, Akke; Cormican, Martin; Hanahoe, Belinda; Murphy, Andrew W. (2011)ABSTRACT: BACKGROUND: Urinary tract infections (UTIs) are the second most common bacterial infections in general practice and a frequent indication for prescription of antimicrobials. Increasing concern about the association ... -
The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives
Cannon, Dara (Nature Publishing Group, 2012)We investigated the role of variation in putative psychosis genes coding for elements of the white matter system by examining the contribution of genotypic variation in three single-nucleotide polymorphisms (SNPs) neuregulin ... -
ATLANTIC DIP: simplifying the follow-up of women with previous gestational diabetes
O'Dea, Angela (European Society of Endocrinology, 2013)Objective: Previous gestational diabetes (GDM) is associated with a significant lifetime risk of type 2 diabetes. In this study, we assessed the performance of HbA1c and fasting plasma glucose (FPG) measurements against ... -
Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: A systematic review and meta-analysis
Cradock, Kevin A.; Ó Laighin, Gearóid; Finucane, Francis M.; Gainforth, Heather L.; Quinlan, Leo R.; Martin Ginis, Kathleen A. (BioMed Central, 2017-02-08)Background: Changing diet and physical activity behaviour is one of the cornerstones of type 2 diabetes treatment, but changing behaviour is challenging. The objective of this study was to identify behaviour change techniques ... -
Behavioural, neurochemical and neuroendocrine effects of the endogenous beta-carboline harmane in fear-conditioned rats
Smith, Karen L.; Ford, Gemma K.; Finn, David P. (2012)The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the ... -
Brain CB2 receptors: Implication for Neuropsychiatric disorders
Roche, Michelle; Finn, David P. (2010)Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression ... -
Career choices of today's medical students: where does surgery rank?
Kerin, Michael J. (Springer, 2013-11-15)The national junior doctor recruitment crisis prompts an appraisal of medical student attitudes to different career pathways. The purpose of this study was to perform a national review of surgical career intentions of Irish ... -
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
Burke, Nikita N.; Finn, David P.; Roche, Michelle (Elsevier, 2015-02)Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ... -
Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat
Roche, Michelle; Harkin, Andrew; Kelly, John P. (2007)The olfactory bulbectomized (OB) rat is a well characterized animal model that exhibits a number of behavioural and neurochemical changes that have relevance to clinical depression. Hyperactivity in the open field is the ... -
Circuitry underlying regulation of the serotonergic system by swim stress
Roche, Michelle; Commons, Kathryn G.; Peoples, Andrew; Valentino, Rita J. (Society for Neuroscience, 2003-02-01)The dorsal raphe nucleus (DR)–serotonin (5-HT) system has been implicated in depression and is dramatically affected by swim stress, an animal model with predictive value for antidepressants. Accumulating evidence implicates ... -
Clinical applications of gene expression in colorectal cancer.
Kerin, Michael J. (2013)Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ... -
Cognitive course in first-episode psychosis and clinical correlates: A 4year longitudinal study using the MATRICS Consensus Cognitive Battery.
Kenney, Joanne; Anderson-Schmidt, Heike; Scanlon, Cathy; Arndt, Sophia; Scherz, Elisabeth; McInerney, Shane; McFarland, John; Byrne, Fintan; Ahmed, Mohamed; Donohoe, Gary; Hallahan, Brian; McDonald, Colm; Cannon, Dara M. (2015-09-26)While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of ... -
A comparison of the teamwork attitudes and knowledge of Irish surgeons and U.S Naval aviators.
O'Connor, Paul; Ryan, Stephen; Keogh, Ivan (Elsevier, 2012-10)Poor teamwork skills are contributors to poor performance and mishaps in high risk work settings, including the operating theatre. A questionnaire was used to assess the attitudes towards, and knowledge of, Irish surgeons ... -
Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome.
Scanlon, Cathy; Anderson-Schmidt, Heike; McInerney, Shane; Kenney, Joanne; McFarland, John; Waldron, Mairead; Ambati, Srinath; Fullard, Anna; Logan, Sam; Hallahan, Brian; Elliott, Mark A.; Cannon, Dara M.; McDonald, Colm (Elsevier, 2014-08-11)First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may ... -
The cost effectiveness of the SIMPle intervention to improve antimicrobial prescribing for urinary tract infection in primary care
Gillespie, Paddy; Callan, Aoife; O'Shea, Eamon; Duane, Sinead; Murphy, Andrew W.; Domegan, Christine; Galvin, Sandra; Vellinga, Akke (Oxford University Press, 2016-09-27)Abstract Background Antimicrobial resistance is a major public health issue. This study examines the cost effectiveness of the SIMPle (Supporting the Improvement and Management of Prescribing for Urinary Tract Infections ...