Browsing School of Medicine by Author "|~|"
Now showing items 41-60 of 89
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Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [C-11]DASB
Cannon, Dara (2010)In a previous study we showed that genetic variation in HTR2A, which encodes the serotonin 2A receptor, influenced outcome of citalopram treatment in patients with major depressive disorder. Since chronic administration ... -
Group follow-up compared to individual clinic visits after structured education for type 1 diabetes: A cluster randomised controlled trial
Dinneen, Sean; O'Hara, Mary Clare; Byrne, Molly (Elsevier, 2013-04)Aim - To compare the effectiveness of group follow-up with individual follow-up after participation in the Dose Adjustment for Normal Eating (DAFNE) structured education programme. Methods - Cluster randomised controlled ... -
Home detection of freezing of gait using support vector machines through a single waist-worn triaxial accelerometer
Rodríguez-Martín, Daniel; Samà, Albert; Pérez-López, Carlos; Català, Andreu; Moreno Arostegui, Joan M.; Cabestany, Joan; Bayés, Àngels; Alcaine, Sheila; Mestre, Berta; Prats, Anna; Cruz Crespo, M.; Counihan, Timothy J.; Browne, Patrick; Quinlan, Leo R.; Ó Laighin, Gearóid; Sweeney, Dean; Lewy, Hadas; Azuri, Joseph; Vainstein, Gabriel; Annicchiarico, Roberta; Costa, Alberto; Rodríguez-Molinero, Alejandro (Public Library of Science, 2017-02-15)Among Parkinson's disease (PD) symptoms, freezing of gait (FoG) is one of the most debilitating. To assess FoG, current clinical practice mostly employs repeated evaluations over weeks and months based on questionnaires, ... -
Identifying and addressing the limitations of safety climate surveys.
O'Connor, Paul (Elsevier, 2011-06)This paper reports the descriptive analysis of a large sample of safety climate survey data (n = 110,014) collected over 10 years from U.S. Naval aircrew using the Command Safety Assessment Survey (CSAS). -
Impact of working 48 hours per week on opportunities for training and patient contact: the experience of Irish interns
O'Connor, Paul; Ahern, Sean; Moloney, Brian; Lydon, Sinéad; Byrne, Dara (Oxford University Press, 2015-09-29)Objective. The European Working Time Regulations (EWTR) have been criticised for its purported negative impact on the training of junior doctors. The aim of this study was to examine the amount of time interns spent ... -
Indistinguishable NDM-producing escherichia coli isolated from recreational waters, sewage, and a clinical specimen in Ireland, 2016 to 2017
Mahon, Bláthnaid M.; Brehony, Carina; McGrath, Elaine; Killeen, James; Cormican, Martin; Hickey, Paul; Keane, Shane; Hanahoe, Belinda; Dolan, Ann; Morris, Dearbháile (European Centre for Disease Prevention and Control, 2017-04-13)In this study, New Delhi metallo-beta-lactamase (NDM)-producing Enterobacteriaceae were identified in Irish recreational waters and sewage. Indistinguishable NDM-producing Escherichia coli by pulsed-field gel electrophoresis ... -
Inertial sensor technology for elite swimming performance analysis: a systematic review
Mooney, Robert; Corley, Gavin; Godfrey, Alan; Quinlan, Leo R.; Ó Laighin, Gearóid (MDPI, 2015-12-25)Technical evaluation of swimming performance is an essential factor of elite athletic preparation. Novel methods of analysis, incorporating body worn inertial sensors (i.e., Microelectromechanical systems, or MEMS, ... -
Interns and their smartphones: use for clinical practice
O'Connor, Paul; Byrne, Darra; Butt, M.; Lydon, S.; Stewart, Brian; Kerin, M. J. (Medscape, 2014)Purpose of the study Smartphone use among healthcare professionals has become widespread and will continue to grow in the coming years.Study design In October 2012, a survey was distributed to 230 interns at two of the ... -
Intervention to improve the quality of antimicrobial prescribing for urinary tract infection: a cluster randomized trial
Vellinga, Akke; Galvin, Sandra; Duane, Sinead; Callan, Aoife; Bennett, Kathleen; Cormican, Martin; Domegan, Christine; Murphy, Andrew W. (Canadian Medical Association, 2015-11-16)Background: Overuse of antimicrobial therapy in the community adds to the global spread of antimicrobial resistance, which is jeopardizing the treatment of common infections.Methods: We designed a cluster randomized complex ... -
Investigating the management of diabetes in nursing homes using a mixed methods approach
Hurley, Lorna; O'Donnell, Máire; Ó Caoimh, Ronan; Dinneen, Seán F. (Elsevier ScienceDirect, 2017-03-21)Aims: As populations age there is an increased demand for nursing home (NH) care and a parallel increase in the prevalence of diabetes. Despite this, there is growing evidence that the management of diabetes in NHs is ... -
The Irish DAFNE Study Protocol: A cluster randomised trial of group versus individual follow-up after structured education for Type 1 diabetes
Dinneen, Seán F.; O' Hara, Mary Clare; Byrne, Molly; Newell, John; Daly, Lisa (2009)Background: Structured education programmes for individuals with Type 1 diabetes have become a recognised means of delivering the knowledge and skills necessary for optimal self-management of the condition. The Dose ... -
Is diabetes self-management education still the Cinderella of diabetes care?
Hurley, Lorna; O’Donnell, Máire; O’Hara, Mary Clare; Carey, Marian E.; Willaing, Ingrid; Daly, Heather; Dinneen, Seán F. (Elsevier ScienceDirect, 2017-05-17)This paper reflects on the status of diabetes self-management education (DSME) as a branch of diabetology in Europe and discusses some opportunities for better supporting DSME delivery. DSME (also commonly known as Therapeutic ... -
Isolation of secreted microRNAs (miRNAs) from cell-conditioned media
Glynn, Claire L.; Khan, Sonja; Kerin, Michael J.; M. Dwyer, Roisin (2013)MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ... -
The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer
Kerin, Michael J.; McVeigh, Terri; Dorairaj, Jemima J.; Heneghan, Helen M.; Miller, Nicola (2012)Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian ... -
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-03-27)Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ... -
Linguistic and Psychometric Validation of the Diabetes-Specific Quality-of-Life Scale in UK English for Adults With Type 1 Diabetes
O' Hara, Mary Clare; Dinneen, Sean (American Diabetes Association, 2012-12-18)OBJECTIVE-To develop a linguistically and psychometrically validated U.K. English (U.K.! Ireland) version of the Diabetes-Specific Quality-of-Life Scale (DSQOLS) for adults with type 1 diabetes.RESEARCH DESIGN AND METHODS-We ... -
A longitudinal qualitative study examining the factors impacting on the ability of persons with T1DM to assimilate the Dose Adjustment For Normal Eating (DAFNE) principles into daily living and how these factors change over time
Murphy, Kathy; Casey, Dympna; Dinneen, Sean (BioMed Central, 2011-08-30)The literature reveals that structured education programmes, such as DAFNE, result in many positive outcomes for people with Type 1 diabetes including a decrease in HbA1c levels and reductions in hypoglycaemia. While there ... -
Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
Burke, Nikita N.; Llorente, Ricardo; Marco, Eva M.; Tong, Kezanne; Finn, David P.; Viveros, Maria-Paz; Roche, Michelle (Elsevier, 2013-10)Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ... -
Medical speciality choices: Does personality matter?
O'Connor, Paul (Irish Medical Journal, 2015-08-07)There has been increasing interest in the personalities of doctors. This study examined whether personality differed based upon gender, level of training or medical speciality among 200 physicians and 134 medical students. ... -
A meta-analysis of the effectiveness of crew resource management training in acute care domains.
O'Dea, Angela; O'Connor, Paul; Keogh, Ivan (2014)The healthcare industry has seen an increase in the adoption of team training, such as crew resource management (CRM), to improve teamwork and coordination within acute care medical teams. A meta-analysis was carried out ...