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Proactive esophageal cooling during laser cardiac ablation: A computer modeling study
(Wiley, 2024-03-04)Background and Objectives Laser ablation is increasingly used to treat atrial fibrillation (AF). However, atrioesophageal injury remains a potentially serious complication. While proactive esophageal cooling (PEC) reduces ... -
Disturbing effect of intra-tissue temperature sensors in pre-clinical experimental studies of radiofrequency cardiac ablation: A computer-based modeling study
(MDPI, 2023-04-11)Background: Preclinical studies on radiofrequency (RF) cardiac ablation (RFCA) use very small temperature sensors in specific positions in the tissue subjected to RF heating. Despite the sensors¿ small size, the proximity ... -
How intramyocardial fat can alter the electric field distribution during Pulsed Field Ablation (PFA): Qualitative findings from computer modeling
(Public Library of Science, 2023-11-02)Even though the preliminary experimental data suggests that cardiac Pulsed Field Ablation (PFA) could be superior to radiofrequency ablation (RFA) in terms of being able to ablate the viable myocardium separated from the ... -
Low-frequency electrical conductivity of trabecular bone: Insights from in silico modeling
(MDPI, 2023-09-23)Background: The electrical conductivity of trabecular bone at 100 kHz has recently been reported as a good predictor of bone volume fraction. However, quantifying its relationship with free water (or physiological solution) ... -
Cardioneuroablation using epicardial pulsed field ablation for the treatment of atrial fibrillation
(MDPI, 2023-05-29)Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and ... -
How far the zone of heat-induced transient block extends beyond the lesion during RF catheter cardiac ablation
(Taylor and Francis Group, 2023-01-02)Purpose While radiofrequency catheter ablation (RFCA) creates a lesion consisting of the tissue points subjected to lethal heating, the sublethal heating (SH) undergone by the surrounding tissue can cause transient ... -
Analysis of thermal effects from pulsed field ablation
(Oxford University Press, 2023-11-09)Background Pulsed field ablation (PFA) has been described as non-thermal, but abundant data exist in oncology applications [1-3], and growing data are emerging in cardiology [4], highlighting that thermal effects are in ... -
Impact of ultra-short pauses between stacked lesions with and without active esophageal cooling
(Oxford University Press, 2023-05-24)Background Placing lesions at the same point (stacking lesions) in the left atrium during radiofrequency (RF) ablation can increase the risk of collateral injury. The use of active esophageal cooling has been shown to ... -
Epicardial pulsed field ablation of ganglionated plexi: Computational and pre-clinical evaluation of a bipolar sub-xiphoid catheter for the treatment of atrial fibrillation
(MDPI, 2023-12-24)Epicardial pulsed field ablation (PFA) of ganglionated plexi (GPs) is being explored as a potential treatment for atrial fibrillation. Initial work using open-chest access with a monopolar ablation device has been completed. ... -
Relationship between mechanical deformation and contact force applied by a catheter tip on cardiac muscle: Experimentation and computer modeling
(IEEE, 2023-08-25)The cardiac muscle is elastic and deformable. Pushing a catheter in contact with the cardiac muscle surface to conduct focal energy-based ablative therapies, such as RF ablation, requires an adequate electrode-tissue contact ... -
The emerging spectrum of fetal acetylcholine receptor antibody-related disorders (FARAD)
(Oxford University Press, 2023-05-15)In utero exposure to maternal antibodies targeting the fetal acetylcholine receptor isoform (fAChR) can impair fetal movement, leading to arthrogryposis multiplex congenita (AMC). Fetal AChR antibodies have also been ... -
Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies
(Elsevier, 2023-10-23)Background Mesenchymal stromal cells (MSCs) show great potential for immunomodulatory and anti-inflammatory treatments. Clinical trials have been performed for the treatment of Type 1 diabetes, graft-versus-host disease ... -
A systematic review of the use of positive deviance approaches in primary care
(Oxford University Press, 2021-11-25)Abstract Background: The Positive Deviance (PD) approach focuses on identifying and learning from those who demonstrate exceptional performance despite facing similar resource constraints to others. Recently, it has been ... -
S100b in acute ischemic stroke clots is a biomarker for post-thrombectomy intracranial hemorrhages
(Frontiers Media, 2023-01-23)Background and purpose: Post-thrombectomy intracranial hemorrhages (PTIH) are dangerous complications of acute ischemic stroke (AIS) following mechanical thrombectomy. We aimed to investigate if S100b levels in AIS clots ... -
Detection, diagnosis and treatment of acute ischemic stroke: Current and future perspectives
(Frontiers Media, 2022-06-24)Stroke is one of the leading causes of disability worldwide. Early diagnosis and treatment of stroke are important for better clinical outcome. Rapid and accurate diagnosis of stroke subtypes is critical. This review ... -
Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry
(Springer, 2021-08-20)Background and purpose There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT ... -
The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome
(Springer, 2020-09-16)Both intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are evidence-based treatments for acute ischemic stroke (AIS) in selected cases. Recanalization may occur following IVT without the necessity of further ... -
Potential biomarkers of acute ischemic stroke etiology revealed by mass spectrometry based proteomic characterization of formalin-fixed paraffin-embedded blood clots
(Frontiers Media, 2022-04-19)Background and Aims: Besides the crucial role in the treatment of acute ischemic stroke (AIS), mechanical thrombectomy represents a unique opportunity for researchers to study the retrieved clots, with the possibility of ... -
Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization
(SAGE Publications, 2021-07-07)Introduction We assessed the correlation between thrombus size before and after mechanical thrombectomy, measured as length by Computed Tomography Angiography/Non-Contrast Computed Tomography (CTA/NCCT) and Extracted Clot ... -
A standardized aspiration-first approach for thrombectomy to increase speed and improve recanalization rates
(American Society of Neuroradiology, 2019-08-14)BACKGROUND AND PURPOSE: Direct aspiration is a recognized technique for revascularization in large-vessel ischemic strokes. There is ongoing debate regarding its efficacy compared with stent retrievers. Every delay in ...