Browsing College of Medicine, Nursing and Health Sciences by Author "McGuire, Brian E."
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ATLANTIC-DIP- Prevalence of metabolic syndrome and insulin resistance in women with previous gestational diabetes mellitus by International Association of Diabetes in Pregnancy Study Groups criteria
Noctor, Eoin; Crowe, Catherine; Carmody, Louise A.; Kirwan, Breda; O¿Dea, Angela; Glynn, Liam G.; McGuire, Brian E.; O¿Shea, Paula M.; Dunne, Fidelma P. (Springer, 2014-07-08)Women with previous gestational diabetes (GDM) are a high-risk group for future development of diabetes, metabolic syndrome, and cardiovascular disease. The new International Association of Diabetes in Pregnancy Study ... -
Cognitive impairment in patients with chronic neuropathic or radicular pain: An interaction of pain and age
Moriarty, Orla; Ruane, Nancy; O'Gorman, David; Maharaj, Chris H.; Mitchell, Caroline; Sarma, Kiran M.; Finn, David P.; McGuire, Brian E. (Frontiers Media, 2017-06-13)A growing body of empirical research has confirmed an association between chronic pain and cognitive dysfunction. The aim of the present study was to determine whether cognitive function is affected in patients with a ... -
Comparing the clinical-effectiveness and cost-effectiveness of an internet-delivered Acceptance and Commitment Therapy (ACT) intervention with a waiting list control among adults with chronic pain: study protocol for a randomised controlled trial
Hayes, Sara; Hogan, Michael; Dowd, Haulie; Doherty, Edel; O'Higgins, Siobhan; Nic Gabhainn, Saoirse; MacNeela, Padraig; Murphy, Andrew W.; Kropmans, Thomas; O'Neill, Ciaran; Newell, John; McGuire, Brian E. (BMJ Publishing Group, 2014-07-02)Internet-delivered psychological interventions among people with chronic pain have the potential to overcome environmental and economic barriers to the provision of evidence-based psychological treatment in the Irish health ... -
The effect of pain on cognitive function: a review of clinical and preclinical research.
Moriarty, Orla; McGuire, Brian E.; Finn, David P. (2011)Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population. Here we review clinical ... -
Effectiveness of a biopsychosocial e-learning intervention on the clinical judgements of medical students and GP trainees regarding future risk of disability in patients with chronic lower back pain: study protocol for a randomised controlled trial
Dwyer, Christopher P.; Durand, Hannah; MacNeela, Pádraig; Reynolds, Bronagh; Hamm, Robert M.; Main, Christopher J.; O’Connor, Laura L.; Conneely, Sinéad; Taheny, Darragh; Slattery, Brian W.; O’Neill, Ciaran; Nic Gabhainn, Saoirse; Murphy, Andrew W .; Kropmans, Thomas; McGuire, Brian E. (BMJ Publishing Group, 2016-03-16)Introduction Chronic lower back pain (CLBP) is a major healthcare problem with wide ranging effects. It is a priority for appropriate management of CLBP to get individuals back to work as early as possible. Interventions ... -
An evaluation of MyAction, a community-based lifestyle and medical risk factor modification programme, in women with prior gestational diabetes mellitus: study protocol for a randomised controlled trial
Infanti, Jennifer J.; Dunne, Fidelma P.; Gillespie, Paddy; Glynn, Liam G.; Noctor, Eoin; Newell, John; McGuire, Brian E.; O'Dea, Angela (BioMed Central, 2013-05-02)Universal screening using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria has identified a prevalence of gestational diabetes mellitus (GDM) of 12.4% in women living in Ireland. Women ... -
Impaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathy
Moriarty, Orla; Lang, Yvonne; Idrees, Zubair; McGuire, Brian E.; Finn, David P. (Elsevier, 2016-01-13)Diabetes, and associated diabetic neuropathic pain, impact negatively on cognitive function. However, the underlying mechanisms remain poorly understood. This study investigated neuropathic pain-related behaviour and ... -
Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain
Moriarty, Orla; Gorman, Claire L.; McGowan, Fiona; Ford, Gemma K.; Roche, Michelle; Thompson, Kerry; Dockery, Peter; McGuire, Brian E.; Finn, David P. (De Gruyter, 2016-01-01)Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural mechanisms involved are poorly understood. Chronic pain is associated with changes in synaptic plasticity in the brain which ... -
Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats
O’Sullivan, Grace; Humphrey, Rachel M.; Thornton, Aoife M.; Kerr, Daniel M.; McGuire, Brian E.; Caes, Line; Roche, Michelle (Elsevier, 2020-05-30)The influence of parental support on child pain experiences is well recognised. Accordingly, animal studies have revealed both short- and long-term effects of early life stress on nociceptive responding and neural substrates ... -
The prevalence, impact and cost of chronic non-cancer pain in Irish primary schoolchildren (PRIME-C): protocol for a longitudinal school-based survey
O'Higgins, Siobhán; Doherty, Edel; Nic Gabhainn, Saoirse; Murphy, Andrew; Hogan, Michael; O'Neill, Ciaran; McGuire, Brian E. (BMJ Publishing Group, 2015-05-14)Introduction Previous research has indicated that pain influences children's daily lives, resulting in absence from school, sleep problems, poor school performance and problems with social activities. Our study aims to ... -
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
Burke, Nikita N.; Finn, David P.; McGuire, Brian E.; Roche, Michelle (Wiley, 2016-07-12)A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases ... -
Reasons for participation and non-participation in a diabetes prevention trial among women with prior gestational diabetes mellitus (GDM)
Infanti, Jennifer J.; O'Dea, Angela; McGuire, Brian E.; Newell, John; Glynn, Liam G.; O'Neill, Ciaran; Connolly, Susan B.; Dunne, Fidelma P. (Springer, 2014-01)Background: Gestational diabetes mellitus (GDM) is a risk factor for the development of type 2 diabetes. Lifestyle intervention can prevent progression to type 2 diabetes in high risk populations. We designed a randomised ... -
Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain
Moriarty, Orla; Roche, Michelle; McGuire, Brian E.; Finn, David P. (Elsevier, 2011-11)Chronic pain is associated with cognitive deficits. Considerable overlap in brain regions involved in pain and aversion suggests that aversive learning and memory may be affected during chronic pain. Passive-avoidance ...