Browsing College of Medicine, Nursing and Health Sciences by Author "McDonald, Colm"
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Bipolar disorder and gender are associated with frontolimbic and basal ganglia dysconnectivity: A study of topological variance using network analysis
Nabulsi, Leila; McPhilemy, Genevieve; Kilmartin, Liam; O'Hora, Denis; O'Donoghue, Stefani; Forcellini, Giulia; Najt, Pablo; Ambati, Srinath; Costello, Laura; Byrne, Fintan; McLoughlin, James; Hallahan, Brian; McDonald, Colm; Cannon, Dara M. (Mary Ann Liebert, 2019-12-16)Well-established structural abnormalities, mostly involving the limbic system, have been associated with disorders of emotion regulation. Understanding the arrangement and connections of these regions with other functionally ... -
The clinical characteristics and correlates of lithium toxicity in a tertiary referral centre
Ganter, Niamh M.; Tong, Kezanne; McDonald, Colm; Doherty, Anne M. (Springer Verlag, 2019-01-10)Introduction Lithium is a medication indicated for the treatment of bipolar disorder and treatment-resistant depression, with a narrow therapeutic index. Overdose, either acute or chronic can result in neurological symptoms, ... -
Cognitive course in first-episode psychosis and clinical correlates: A 4year longitudinal study using the MATRICS Consensus Cognitive Battery.
Kenney, Joanne; Anderson-Schmidt, Heike; Scanlon, Cathy; Arndt, Sophia; Scherz, Elisabeth; McInerney, Shane; McFarland, John; Byrne, Fintan; Ahmed, Mohamed; Donohoe, Gary; Hallahan, Brian; McDonald, Colm; Cannon, Dara M. (2015-09-26)While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of ... -
Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome.
Scanlon, Cathy; Anderson-Schmidt, Heike; McInerney, Shane; Kenney, Joanne; McFarland, John; Waldron, Mairead; Ambati, Srinath; Fullard, Anna; Logan, Sam; Hallahan, Brian; Elliott, Mark A.; Cannon, Dara M.; McDonald, Colm (Elsevier, 2014-08-11)First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may ... -
Free water elimination and mapping from diffusion tensor imaging (DTI) in chronic schizophrenia
Colgan, Niall; O'Reilly, David; Holleran, Laurena; Ahmed, Mohamed; McDonald, Colm; Cannon, Dara M. (NUI Galway, 2017-06-11)Diffusion tensor imaging (DTI) acquisitions allows the comparison of diffusion characteristics in vivo and gives a unique insight into tissue structure and pathology. However, a limitation of DTI post-processing is the ... -
Frontolimbic, frontoparietal, and default mode involvement in functional dysconnectivity in psychotic bipolar disorder
Nabulsi, Leila; McPhilemy, Genevieve; Kilmartin, Liam; Whittaker, Joseph R.; Martyn, Fiona M.; Hallahan, Brian; McDonald, Colm; Murphy, Kevin; Cannon, Dara M. (Elsevier, 2019-11-11)BACKGROUND: Functional abnormalities, mostly involving functionally specialized subsystems, have been associated with disorders of emotion regulation such as bipolar disorder (BD). Understanding how independent functional ... -
Neuroanatomical dysconnectivity underlying cognitive deficits in bipolar disorder
McPhilemy, Genevieve; Nabulsi, Leila; Kilmartin, Liam; O’Hora, Denis; O’Donoghue, Stefani; Tronchin, Giulia; Costello, Laura; Najt, Pablo; Ambati, Srinath; Neilsen, Gráinne; Creighton, Sarah; Byrne, Fintan; McLoughlin, James; McDonald, Colm; Hallahan, Brian; Cannon, Dara M. (Elsevier, 2019-09-18)BACKGROUND: Graph theory applied to brain networks is an emerging approach to understanding the brain's topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder ... -
Structural connectivity and rich-club organization in recent onset psychosis
Forcellini, Giulia; O'Donoghue, Stefani; Kenney, Joanne; McInerney, Shane; Scanlon, Cathy; Nabulsi, Leila; McPhilemy, Genevieve; Kilmartin, Liam; O'Hora, Denis; Hallahan, Brian; Cannon, Dara M.; McDonald, Colm (Elsevier, 2017-05-17)[No abstract available]