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Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor.

ARAN - Access to Research at NUI Galway

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dc.contributor.author O'Brien, Margaret en
dc.contributor.author Morrison, John J. en
dc.contributor.author Smith, Terry en
dc.date.accessioned 2010-02-09T15:22:43Z en
dc.date.available 2010-02-09T15:22:43Z en
dc.date.issued 2008 en
dc.identifier.citation O' Brien M., Morrison J. J. & Smith T. J. (2008). Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor. Reprod Sci. 2008 Apr;15(4):382-93. en
dc.identifier.uri http://hdl.handle.net/10379/693 en
dc.description.abstract The regulatory mechanisms underlying myometrial smooth muscle contractility during labor are poorly understood. The authors therefore investigated the transcriptional profile of the changes that occur in the human myometrium at term pregnancy when compared with that at labor. Microarray technology was used to identify differentially expressed genes in human myometrium at labor. Real-time fluorescence reversetranscriptase polymerase chain reaction (RT-PCR) was subsequently performed to verify the microarray data. Semiquantitative RT-PCR, Western blotting, and microscopy methodologies were also used. Certain novel genes were found to be upregulated in human myometrium at labor. Of these, PSCDBP, TLR2, TWIST1 , FLJ35382, andRGS12 have not been previously characterized or identified in human myometrium. EDNRB is the other novel labor-associated gene whose reported expression is also upregulated at labor. All 6 genes were expressed on human myometrial smooth muscle cells. These novel upregulated genes are involved in multiple pathways that may be associated with a variety of cellular processes including inflammation, transcriptional regulation, and intracellular signaling. en
dc.format application/pdf en
dc.language.iso en en
dc.publisher Sage en
dc.subject.lcsh Labour en
dc.subject.lcsh Genetics en
dc.subject.lcsh Pregnancy en
dc.title Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor. en
dc.type Article en
dc.local.publishedsource http://rsx.sagepub.com/cgi/reprint/15/4/382 en
dc.description.peer-reviewed peer-reviewed en

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