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Gene therapy in transplantation: Toward clinical trials

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dc.contributor.author Ritter, Thomas en
dc.date.accessioned 2009-11-23T09:48:19Z en
dc.date.available 2009-11-23T09:48:19Z en
dc.date.issued 2009 en
dc.identifier.citation T. Ritter, M. Nosov & M.D. Griffin (2009), "Gene therapy in transplantation: Toward clinical trials", Current Opinion in Molecular Therapeutics 2009, 11:504-512 en
dc.identifier.uri http://hdl.handle.net/10379/410 en
dc.description.abstract The genetic modification of organs or cells is an attractive approach to protect allogeneic transplants from acute rejection and other complications. The transplant setting offers a unique opportunity to utilise ex vivo gene therapy for modification of allogeneic organs and tissues prior to implantation. Significant challenges to applying this concept to human organ transplantation, however, include the large number of potential molecular targets, the diversity and safety profile of available vector delivery systems and the merging of gene-based therapies with existing immunosuppressive regimens. Accordingly many different therapeutic concepts and vector systems have been investigated in the pre-clinical area with a view to prolonging allograft survival but translation of promising gene therapy strategies to human clinical transplant studies has lagged behind the progress seen in other medical fields. In this article recent pre-clinical experimental applications of gene transfer to transplantation are outlined and the degree to which gene therapy has been clinically tested in organ transplant recipients is critically reviewed. en
dc.format application/pdf en
dc.language.iso en en
dc.publisher Thompson en
dc.subject Viral vectors en
dc.subject Transplantation en
dc.subject Gene therapy en
dc.subject Allograft rejection en
dc.subject Clinal trials en
dc.subject Immune tolerance en
dc.subject.lcsh Clinical trials en
dc.subject.lcsh Immunological tolerance en
dc.subject.lcsh Virology en
dc.subject.lcsh Genetic vectors en
dc.subject.lcsh Genetic transformation en
dc.subject.lcsh Gene therapy en
dc.subject.lcsh Transplantation of organs, tissues, etc. en
dc.title Gene therapy in transplantation: Toward clinical trials en
dc.type Article en
dc.description.peer-reviewed peer-reviewed en

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