Browsing Regenerative Medicine Institute (Scholarly Articles) by Title
Now showing items 32-41 of 41
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Mesenchymal stromal cell–based therapies for acute kidney injury: progress in the last decade
(Elsevier, 2020-01-28)A little over 10 years ago, the therapeutic potential of mesenchymal stromal cells (MSCs) for the treatment of acute kidney injury (AKI) was becoming widely recognized. Since then, there has been further intensive study ... -
A novel high-throughput screening platform identifies itaconate derivatives from marine Penicillium antarcticum as inhibitors of mesenchymal stem cell differentiation
(MDPI, 2020-04-05)Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation. Current ... -
Permissive roles of cytokines Interleukin-7 and Flt3-ligand in mouse B cell lineage commitment
(National Academy of Sciences, 2016-11-04)Hematopoietic cells are continuously generated throughout life from hematopoietic stem cells, thus making hematopoiesis a favorable system to study developmental cell lineage commitment. The main factors incorporating ... -
Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression
(Wiley, 2018-03-05)Human blood monocytes are subclassified as classical, intermediate and nonclassical. In this study, it was shown that conventionally defined human intermediate monocytes can be divided into two distinct subpopulations with ... -
Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential
(Nature Research, 2019-12-05)Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and ... -
Pro-B cells propagated in stromal cell-free cultures reconstitute functional B-cell compartments in immunodeficient mice
(Wiley, 2016-12-28)Up to now long-term in vitro growth of pro-B cells was thought to require stromal cells. However, here we show that fetal liver (FL) and bone marrow (BM) derived pro-B cells can be propagated long-term in stromal cell-free ... -
Progress toward the clinical application of mesenchymal stromal cells and other disease-modulating regenerative therapies
(American Society of Nephrology, 2021-01-27)Drawing from basic knowledge of stem cell biology, embryonic development, wound healing and aging, regenerative medicine seeks to develop therapeutic strategies that complement or replace conventional treatments by actively ... -
The secretome derived from mesenchymal stromal cells cultured in a xeno-free medium promotes human cartilage recovery in vitro
(Frontiers Media, 2020-02-14)Osteoarthritis (OA) is a disabling joint disorder causing articular cartilage degeneration. Currently, the treatments are mainly aimed to pain and symptoms relief, rather than disease amelioration. Human bone marrow stromal ... -
Sterile post-traumatic immunosuppression
(Nature Publishing Group, 2016-04-29)After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. ... -
TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo
(Elsevier, 2020-05-29)Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ...