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Models of flow-induced loading on blood cells in laminar and turbulent flow, with application to cardiovascular device flow

ARAN - Access to Research at NUI Galway

Show simple item record Quinlan, Nathan J. en Dooley, Patrick N. en 2009-09-28T10:05:24Z en 2009-09-28T10:05:24Z en 2007-08 en
dc.identifier.citation Quinlan, N., & Dooley, P. (2007). Models of Flow-Induced Loading on Blood Cells in Laminar and Turbulent Flow, with Application to Cardiovascular Device Flow. "Annals of Biomedical Engineering", Vol 35(No. 8), pp 1347-1356. en
dc.identifier.uri en
dc.description.abstract Viscous shear stress and Reynolds stress are often used to predict hemolysis and thrombosis due to flow-induced stress on blood elements in cardiovascular devices. These macroscopic stresses are distinct from the true stress on an individual cell, which is determined by the local microscale flow field. In this paper the flow-induced stress on blood cells is calculated for laminar and turbulent flow, using simplified models for cells and for turbulent eddies. The model is applied to estimate shear stress on red blood cells in flow through a prosthetic heart valve, using the energy spectral density measured by Liu et al. [J. Biomech. Eng. 122:118¿124, 2000]. Results show that in laminar flow, the maximum stress on a cell is approximately equal to the macroscopic viscous shear stress. In turbulent flow through a prosthetic heart valve, the estimated root mean square of flow-induced stress on a cell is at least an order of magnitude less than the Reynolds stress. The results support the hypothesis that smaller turbulent eddies cause higher stress on cells. However, the stress due to an eddy depends on the velocity scale of the eddy as well as its length scale. For the heart valve flow investigated, turbulence contributes to flow-induced stress on cells almost equally across a broad range of the frequency spectrum. The model suggests that Reynolds stress alone is not an adequate predictor of cell damage in turbulent flow, and highlights the importance of the energy spectral density. en
dc.format application/pdf en
dc.language.iso en en
dc.publisher Springer en
dc.subject Turbulent blood flow en
dc.subject Laminar blood flow en
dc.subject Prosthetic heart valves en
dc.subject Hemolysis en
dc.subject Reynolds stress en
dc.subject Energy spectral density en
dc.subject.lcsh Blood flow en
dc.subject.lcsh Heart valve prosthesis en
dc.subject.lcsh Hemolysis and hemolysins en
dc.subject.lcsh Spectral energy distribution en
dc.title Models of flow-induced loading on blood cells in laminar and turbulent flow, with application to cardiovascular device flow en
dc.type Article en
dc.local.publishedsource en
dc.local.publisherstatement The original publication is available at en
dc.description.peer-reviewed non-peer-reviewed en

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