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Effect of eddy length scale on mechanical loading of blood cells in turbulent flow

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dc.contributor.author Dooley, Patrick N. en
dc.contributor.author Quinlan, Nathan J. en
dc.date.accessioned 2009-09-28T09:51:05Z en
dc.date.available 2009-09-28T09:51:05Z en
dc.date.issued 2009 en
dc.identifier.citation Dooley, P., & Quinlan, N. (2009). "Effect of Eddy Length Scale on Mechanical Loading of Blood Cells in Turbulent Flow". Annals of Biomedical Engineering. en
dc.identifier.uri http://hdl.handle.net/10379/312 en
dc.description.abstract Non-physiological turbulent blood flow is known to occur in and near implanted cardiovascular devices, but its effects on blood are poorly understood. The objective of this work is to investigate the effect of turbulent eddy length scale on blood cell damage, and in particular to test the hypothesis that only eddies similar in size to blood cells can cause damage. The microscale flow near a red blood cell (RBC) in an idealized turbulent eddy is modelled computationally using an immersed boundary method. The model is validated for the special case of a tank-treading RBC. In comparisons between turbulent flow fields, based on Kolmogorov theory, the model predicts that damage due to the smallest eddies is almost independent of the Kolmogorov length scale. The model predicts that within a given flow field, however, eddies of sub-cellular scale are less damaging than larger eddies. Eddy decay time and the turbulent energy spectral density are highlighted as important factors. The results suggest that Kolmogorov scale is not an adequate predictor of flow-induced blood trauma, and highlights the need for deeper understanding of the microscale structure of turbulent blood flow. en
dc.language.iso en en
dc.subject Turbulent blood flow en
dc.subject Thrombosis en
dc.subject Hemolysis en
dc.subject Red blood cell en
dc.subject Immersed boundary method en
dc.subject.lcsh Blood flow en
dc.subject.lcsh Blood flow -- Measurement en
dc.subject.lcsh Haematology en
dc.subject.lcsh Kolmogorov complexity en
dc.title Effect of eddy length scale on mechanical loading of blood cells in turbulent flow en
dc.type Article en
dc.local.publishedsource http://dx.doi.org/10.1007/s10439-009-9789-8 en
dc.local.publisherstatement The original publication is available at www.springerlink.com en
dc.description.peer-reviewed peer-reviewed en

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