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Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women

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dc.contributor.author Sedano-Balbás, Sara
dc.contributor.author Lyons, Mark
dc.contributor.author Cleary, Brendan
dc.contributor.author Murray, Margaret
dc.contributor.author Gaffney, Geraldine
dc.contributor.author Maher, Majella
dc.date.accessioned 2012-11-13T11:30:57Z
dc.date.available 2012-11-13T11:30:57Z
dc.date.issued 2011
dc.identifier.citation Sara Sedano-Balbás, Mark Lyons, Brendan Cleary, Margaret Murray, Geraldine Gaffney, and Majella Maher, 'Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women,' Journal of Pregnancy, vol. 2011, Article ID 232840, 9 pages, 2011. doi:10.1155/2011/232840 en_US
dc.identifier.uri http://hdl.handle.net/10379/3058
dc.description.abstract The combination of thrombophilia and pregnancy increases the risk of thrombosis and the potential for adverse outcomes during pregnancy. The most significant common inherited risk factor for thrombophilia is activated protein C resistance (APCR), a poor anticoagulant response of APC in haemostasis, which is mainly caused by an inherited single-nucleotide polymorphism (SNP), factor V G1691A (FV Leiden) (FVL), referred as inherited APCR. Changes in the levels of coagulation factors: FV, FVIII, and FIX, and anticoagulant factors: protein S (PS) and protein C (PC) can alter APC function causing acquired APCR. Prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T are prothrombotic SNPs which in association with APCR can also increase the risk of thrombosis amongst Caucasians. In this study, a correlation between an acquired APCR phenotype and increased levels of factors V, VIII, and IX was demonstrated. Thrombophilic mutations amongst our acquired APCR pregnant women cohort are relatively common but do not appear to exert a severe undue adverse effect on pregnancy. en_US
dc.format application/pdf en_US
dc.language.iso en en_US
dc.subject Pregnancy en_US
dc.subject Thrombophilia en_US
dc.subject National Centre for Biomedical Engineering Science en_US
dc.title Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women en_US
dc.type Article en_US
dc.local.publishedsource http://www.hindawi.com/journals/jp/2011/232840/ en_US
dc.description.peer-reviewed peer-reviewed en_US
dc.contributor.funder HRB en_US

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