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A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization

ARAN - Access to Research at NUI Galway

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dc.contributor.author Aied, Ahmed
dc.contributor.author Glynn, Barry
dc.contributor.author Cao, Hongliang
dc.contributor.author Zheng, Yu
dc.contributor.author Pandit, Abhay
dc.contributor.author Wang, Wenxin
dc.date.accessioned 2012-10-25T09:56:07Z
dc.date.available 2012-10-25T09:56:07Z
dc.date.issued 2012-01
dc.identifier.citation Aied, A,Glynn, B,Cao, HL,Zheng, Y,Tai, HY,Pandit, A,Wang, WX (2012) 'A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization'. Polymer Chemistry, 3 :332-334. en_US
dc.identifier.issn 1759-9962
dc.identifier.uri http://hdl.handle.net/10379/3010
dc.description Journal article en_US
dc.description.abstract The early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently been found to be significantly affected in cancer patients, they offer a means of early stage detection of cancer. Towards the goal of creating a novel method of DNA hybridization detection, we report the detection of specific sequences of small oligonucleotides in a model experiment carried out in serum. The results shown here display the versatility of the DE-ATRP method in synthesizing a specific polymer structure capable of changing its physical properties in the presence of double stranded DNA. The polymer was labeled and used to detect single-stranded DNA in serum successfully. en_US
dc.language.iso en en_US
dc.publisher Royal Society of Chemistry en_US
dc.relation.ispartof Polymer Chemistry en
dc.subject Conjugated polymers en_US
dc.subject Micro RNAs en_US
dc.title A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization en_US
dc.type Article en_US
dc.date.updated 2012-10-24T11:58:41Z
dc.identifier.doi DOI 10.1039/c2py00516f
dc.local.publishedsource http://dx.doi.org/10.1039/c2py00516f en_US
dc.description.peer-reviewed peer-reviewed
dc.contributor.funder |~|
dc.internal.rssid 1332727
dc.local.contact Abhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie
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dc.local.version PUBLISHED

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