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DNA Immobilization and Detection on Cellulose Paper using a Surface Grown Cationic Polymer via ATRP

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dc.contributor.author Aied, Ahmed
dc.contributor.author Zheng, Yu
dc.contributor.author Pandit, Abhay
dc.date.accessioned 2012-10-24T11:50:31Z
dc.date.available 2012-10-24T11:50:31Z
dc.date.issued 2012-02-02
dc.identifier.citation Aied, A,Zheng, Y,Pandit, A,Wang, WX (2012) 'DNA Immobilization and Detection on Cellulose Paper using a Surface Grown Cationic Polymer via ATRP'. Acs Applied Materials & Interfaces, 4 :826-831. en_US
dc.identifier.issn 1944-8252
dc.identifier.uri http://hdl.handle.net/10379/3009
dc.description Journal article en_US
dc.description.abstract Cationic polymers with various structures have been widely investigated in the areas of medical diagnostics and molecular, biology because of their unique binding properties and capability to interact with biological molecules in complex biological environments.; In this work-we report the grafting of a linear cationic polymer from an atom transfer radical polymerization (ATRP) initiator bound to cellulose paper surface. We show successful binding of ATRP initiator onto cellulose paper and grafting of polymer chains from the immobilized initiator with ATRP. The cellulose paper grafted polymer was used in combination with PicoGreen (PG) to demonstrate detection of nucleic acids in the nanogram range in homogeneous solution and in a biological sample (serum). The results showed specific identification of hybridized DNA after addition of PG in both solutions. en_US
dc.format application/pdf en_US
dc.language.iso en en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartof Acs Applied Materials & Interfaces en
dc.subject Atom transfer radical polymerization (ATRP) en_US
dc.subject DNA sensors en_US
dc.subject Fluorescence en_US
dc.subject Cationic polymers en_US
dc.subject Oligonucleotides en_US
dc.subject Biomarkers en_US
dc.title DNA Immobilization and Detection on Cellulose Paper using a Surface Grown Cationic Polymer via ATRP en_US
dc.type Article en_US
dc.date.updated 2012-10-18T17:01:30Z
dc.identifier.doi DOI 10.1021/am201483h
dc.local.publishedsource http://dx.doi.org/10.1021/am201483h en_US
dc.description.peer-reviewed peer-reviewed
dc.contributor.funder |~|
dc.internal.rssid 2195942
dc.local.contact Abhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie
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