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The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair

ARAN - Access to Research at NUI Galway

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dc.contributor.author Daly, William T.
dc.contributor.author Yao, Li
dc.contributor.author Abu-Rub, Mohammad
dc.contributor.author Zeugolis, Demitrios
dc.date.accessioned 2012-10-24T10:42:36Z
dc.date.available 2012-10-24T10:42:36Z
dc.date.issued 2012-06-25
dc.identifier.citation Daly, WT,Yao, L,Abu-rub, MT,O'Connell, C,Zeugolis, DI,Windebank, AJ,Pandit, AS (2012) 'The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair'. Biomaterials, 33 :6660-6671. en_US
dc.identifier.issn 0142-9612
dc.identifier.uri http://hdl.handle.net/10379/3006
dc.description Journal article en_US
dc.description.abstract The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. Current clinically approved hollow nerve guidance conduits allow provision of this protective environment; however they fail to provide an essential internal architecture to the regenerating nerve. In the present study both structured and unstructured intraluminal collagen fibres are investigated to assess their ability to enhance conduit mediated nerve repair. This study presents a direct comparison of both structured and unstructured fibres in vivo. The addition of intraluminal guidance structures was shown to significantly decrease axonal dispersion within the conduit and reduced axonal mismatch of distal nerve targets (p en_US
dc.format application/pdf en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartof Biomaterials en
dc.subject Nerve guidance conduit en_US
dc.subject In vivo en_US
dc.subject Biomaterials en_US
dc.subject Peripheral nerve en_US
dc.subject Repair en_US
dc.subject Nerve guide en_US
dc.title The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair en_US
dc.type Article en_US
dc.date.updated 2012-10-18T16:31:08Z
dc.identifier.doi DOI 10.1016/j.biomaterials.2012.06.002
dc.local.publishedsource http://dx.doi.org/10.1016/j.biomaterials.2012.06.002 en_US
dc.description.peer-reviewed peer-reviewed
dc.contributor.funder |~|
dc.internal.rssid 2469046
dc.local.contact Abhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie
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