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Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels

ARAN - Access to Research at NUI Galway

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dc.contributor.author Abu-Rub, Mohammad
dc.contributor.author Zeugolis, Demetrios
dc.contributor.author Pandit, Abhay
dc.date.accessioned 2012-10-24T09:58:51Z
dc.date.available 2012-10-24T09:58:51Z
dc.date.issued 2012-08
dc.identifier.citation Denning, D,Abu-Rub, MT,Zeugolis, DI,Habelitz, S,Pandit, A,Fertala, A,Rodriguez, BJ (2012) 'Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels'. Acta Biomaterialia, 8 :3073-3079. en_US
dc.identifier.issn 1742-7061
dc.identifier.uri http://hdl.handle.net/10379/3005
dc.description Journal article en_US
dc.description.abstract Assembling artificial collagenous tissues with structural, functional, and mechanical properties which mimic natural tissues is of vital importance for many tissue engineering applications. While the electro-mechanical properties of collagen are thought to play a role in, for example, bone formation and remodeling, this functional property has not been adequately addressed in engineered tissues. Here the electro-mechanical properties of rat tail tendon are compared with those of dried isoelectrically focused collagen hydrogels using piezoresponse force microscopy under ambient conditions. In both the natural tissue and the engineered hydrogel D-periodic type I collagen fibrils are observed, which exhibit shear piezoelectricity. While both tissues also exhibit fibrils with parallel orientations, Fourier transform analysis has revealed that the degree of parallel alignment of the fibrils in the tendon is three times that of the dried hydrogel. The results obtained demonstrate that isoelectrically focused collagen has similar structural and electro-mechanical properties to that of tendon, which is relevant for tissue engineering applications. (c) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartof Acta Biomaterialia en
dc.subject Atomic force microscopy en_US
dc.subject Piezoelectricity en_US
dc.subject Collagen en_US
dc.subject Isoelectric focusing en_US
dc.subject Tissue engineering en_US
dc.title Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels en_US
dc.type Article en_US
dc.date.updated 2012-10-18T16:28:39Z
dc.identifier.doi DOI 10.1016/j.actbio.2012.04.017
dc.local.publishedsource http://dx.doi.org/10.1016/j.actbio.2012.04.017 en_US
dc.description.peer-reviewed peer-reviewed
dc.contributor.funder |~|
dc.internal.rssid 2246939
dc.local.contact Abhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie
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