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Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D "Knot" Polymer Structure for Nonviral Gene Delivery

ARAN - Access to Research at NUI Galway

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dc.contributor.author Newland, Ben
dc.contributor.author Zheng, Yu
dc.contributor.author Jin, Yao
dc.contributor.author Abu-Rub, Mohammad
dc.contributor.author Cao, Hongliang
dc.contributor.author Wang, Wenxin
dc.contributor.author Pandit, Abhay
dc.date.accessioned 2012-10-24T09:29:04Z
dc.date.available 2012-10-24T09:29:04Z
dc.date.issued 2012-02-12
dc.identifier.citation Newland, B,Zheng, Y,Jin, Y,Abu-Rub, M,Cao, HL,Wang, WX,Pandit, A (2012) 'Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D Knot Polymer Structure for Nonviral Gene Delivery'. Journal Of The American Chemical Society, 134 :4782-4789. en_US
dc.identifier.issn 1520-5126
dc.identifier.uri http://hdl.handle.net/10379/3002
dc.description Journal article en_US
dc.description.abstract The large research effort focused on enhancing nonviral transfection vectors has clearly demonstrated that their macromolecular structure has a significant effect on their transfection efficacy. The 3D branched polymeric structures, such as dendrimers, have proved to be a very effective structure for polymeric transfection vectors; however, so far the dendritic polymers have not delivered on their promise. This is largely because a wide range of dendritic polymer materials with tailored multifunctional properties and biocompatibility required for such applications are not yet accessible by current routes. Herein, we report the design and synthesis of new 3D "Single Cyclized" polymeric gene vectors with well-defined compositions and functionalities via a one-step synthesis from readily available vinyl monomers. We observe that this polymer structure of a single chain linked to itself interacts differently with plasmid DNA compared to conventional vectors and when tested over a range of cell types, has a superior transfection profile in terms of both luciferase transfection capability and preservation of cell viability. This new knotted structure shows high potential for gene delivery applications through a combination of simplicity in synthesis, scalability, and high performance. en_US
dc.language.iso en en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartof Journal Of The American Chemical Society en
dc.subject Size distribution en_US
dc.subject 3-dimensional polymers en_US
dc.subject Gel formation en_US
dc.subject Star polymers en_US
dc.subject Polyethylenimine en_US
dc.subject Transfection en_US
dc.subject Copolymers en_US
dc.subject Vectors en_US
dc.subject Degradation en_US
dc.subject Progress en_US
dc.title Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D "Knot" Polymer Structure for Nonviral Gene Delivery en_US
dc.type Article en_US
dc.date.updated 2012-10-18T16:19:51Z
dc.identifier.doi DOI 10.1021/ja2105575
dc.local.publishedsource http://dx.doi.org/10.1021/ja2105575 en_US
dc.description.peer-reviewed peer-reviewed
dc.contributor.funder |~|
dc.internal.rssid 2196177
dc.local.contact Abhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie
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