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A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery

ARAN - Access to Research at NUI Galway

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dc.contributor.author Daly, William
dc.contributor.author Yao, Li
dc.contributor.author Zeugolis, Demetrios
dc.contributor.author Pandit, Abhay
dc.date.accessioned 2012-10-23T14:22:22Z
dc.date.available 2012-10-23T14:22:22Z
dc.date.issued 2011-11
dc.identifier.citation Daly, W., Yao, L., Zeugolis. D.I., Windebank, A. and Pandit, A. (2012) 'A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery'. Journal Of The Royal Society Interface, 9 (67):202-221. en_US
dc.identifier.issn 1742-5662
dc.identifier.uri http://hdl.handle.net/10379/2999
dc.description Journal article en_US
dc.description.abstract Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of limitations that need to be addressed. NGCs, in particular, are limited to treating a relatively short nerve gap (4 cm in length) and are often associated with poor functional recovery. Recent advances in biomaterials and tissue engineering approaches are seeking to overcome the limitations associated with these treatment methods. This review critically discusses the advances in biomaterial-based NGCs, their limitations and where future improvements may be required. Recent developments include the incorporation of topographical guidance features and/or intraluminal structures, which attempt to guide Schwann cell (SC) migration and axonal regrowth towards their distal targets. The use of such strategies requires consideration of the size and distribution of these topographical features, as well as a suitable surface for cell-material interactions. Likewise, cellular and molecular-based therapies are being considered for the creation of a more conductive nerve microenvironment. For example, hurdles associated with the short half-lives and low stability of molecular therapies are being surmounted through the use of controlled delivery systems. Similarly, cells (SCs, stem cells and genetically modified cells) are being delivered with biomaterial matrices in attempts to control their dispersion and to facilitate their incorporation within the host regeneration process. Despite recent advances in peripheral nerve repair, there are a number of key factors that need to be considered in order for these new technologies to reach the clinic. en_US
dc.format application/pdf en_US
dc.language.iso en en_US
dc.publisher The Royal Society en_US
dc.relation.ispartof Journal Of The Royal Society Interface en
dc.subject Peripheral nerve conduit en_US
dc.subject Topographical guidance en_US
dc.subject Molecular therapy en_US
dc.subject Schwann cells en_US
dc.subject Stem cells en_US
dc.subject Neurotrophic factors en_US
dc.title A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery en_US
dc.type Article en_US
dc.date.updated 2012-10-18T16:10:52Z
dc.identifier.doi 10.1098/rsif.2011.0438
dc.local.publishedsource http://dx.doi.org/10.1098/rsif.2011.0438 en_US
dc.description.peer-reviewed peer-reviewed
dc.contributor.funder |~|
dc.internal.rssid 1427028
dc.local.contact Abhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie
dc.local.copyrightchecked Yes
dc.local.version ACCEPTED

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