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Can a young muscle s stem cell secretome prolong our lives?

ARAN - Access to Research at NUI Galway

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dc.contributor.author McCullagh, K.J.A.
dc.date.accessioned 2012-07-02T16:11:48Z
dc.date.available 2012-07-02T16:11:48Z
dc.date.issued 2012
dc.identifier.citation McCullagh, KJA (2012) 'Can a young muscle s stem cell secretome prolong our lives?'. Stem Cell Research & Therapy, 3 (3). en_US
dc.identifier.uri http://hdl.handle.net/10379/2895
dc.description.abstract Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important role. Many ageing-associated dysfunctions in stem cells have been described, but it remains ambiguous whether these are merely an outcome of ageing or are causal. Parabiotic animal studies suggest there are factors in the systemic environment that can infl uence the regenerative capacity of tissues. These factors can be altered by ageing, but it is not clear where these age-dependent factors are derived. A recent provocative study on muscle stem cells, in a mouse model of human progeria, proposes a mechanism that might provide answers to these fundamental ageing questions. en_US
dc.format application/pdf en_US
dc.language.iso en en_US
dc.relation.ispartof Stem Cell Research & Therapy en
dc.subject Progeria en_US
dc.subject Ageing en_US
dc.title Can a young muscle s stem cell secretome prolong our lives? en_US
dc.type Article en_US
dc.date.updated 2012-07-02T15:51:06Z
dc.local.publishedsource http://stemcellres.com/content/3/3/19 en_US
dc.description.peer-reviewed peer-reviewed
dc.contributor.funder |~|Health Research Board|~|
dc.internal.rssid 1901166
dc.local.contact Karl Mccullagh, Dept Of Physiology, Quadrangle Building, Nui Galway. 4220 Email: karl.mccullagh@nuigalway.ie
dc.local.copyrightchecked Yes
dc.local.version ACCEPTED

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