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Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor

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dc.contributor.author Kerr, D.M.
dc.contributor.author Burke, N.N.
dc.contributor.author Ford, Gemma K.
dc.contributor.author Harhen, Brendan
dc.contributor.author Egan, Laurence J.
dc.contributor.author Finn, David P.
dc.contributor.author Roche, Michelle
dc.date.accessioned 2012-01-24T10:36:50Z
dc.date.available 2012-01-24T10:36:50Z
dc.date.issued 2011-09
dc.identifier.citation Kerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Finn DP and Roche M (2011). Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor. Neuroscience en_US
dc.identifier.uri http://hdl.handle.net/10379/2529
dc.description.abstract The endocannabinoid system is an important regulator of the nervous, neuroendocrine, and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, there is a paucity of data relating to the effects of endocannabinoids on neuroinflammatory mediators following an immune stress/challenge in vivo. This study investigated the effects of URB597, a selective inhibitor of fatty acid amide hydrolyase (FAAH), the enzyme that preferentially metabolizes anandamide, on lipopolysaccharide (LPS)-induced increases in the expression of immune mediators in the hypothalamus. Systemic administration of URB597 increased the levels of anandamide and the related N-acylethanolamines, N-palmitoylethanolamide, and N-oleoylethanolamide, but not 2-arachidonoyl glycerol, in the hypothalamus and spleen. URB597 attenuated the LPS-induced increase in interleukin (IL)-1 expression while concurrently augmenting the LPS-induced increase in suppressor of cytokine signalling (SOCS)-3 expression. In addition, URB597 tended to enhance and reduce the LPS-induced increase in IL-6 and IL-10 mRNA expression, respectively. LPS-induced increases in peripheral cytokine levels or plasma corticosterone were not altered by URB597. The present study provides evidence for a role for FAAH in the regulation of LPS-induced expression of inflammatory mediators in the hypothalamus. Improved understanding of endocannabinoid-mediated regulation of neuroimmune function has fundamental physiological and potential therapeutic significance in the context of stress-related disorders. en_US
dc.format application/pdf en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Endocannabinoid en_US
dc.subject Anandamide en_US
dc.subject 2-AG en_US
dc.subject Cytokine en_US
dc.subject HPA axis en_US
dc.subject Pharmacology & Therapeutics en_US
dc.title Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor en_US
dc.type Article en_US
dc.local.publisherstatement http://dx.doi.org/10.1016/j.neuroscience.2011.09.032 en_US
dc.description.peer-reviewed peer-reviewed en_US
dc.contributor.funder Science Foundation Ireland en_US

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