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Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain

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dc.contributor.author Moriarty, Orla
dc.contributor.author Roche, Michelle
dc.contributor.author McGuire, Brian E.
dc.contributor.author Finn, David P.
dc.date.accessioned 2012-01-24T10:34:21Z
dc.date.available 2012-01-24T10:34:21Z
dc.date.issued 2011-11
dc.identifier.citation Moriarty O, Roche, M, McGuire BE, Finn DP (2011). Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain. Journal of Neuroscience Methods, 204(1):1-8. en_US
dc.identifier.uri http://hdl.handle.net/10379/2528
dc.description.abstract Chronic pain is associated with cognitive deficits. Considerable overlap in brain regions involved in pain and aversion suggests that aversive learning and memory may be affected during chronic pain. Passive-avoidance paradigms traditionally use foot-shock to induce context-conditioned avoidance and may be unsuitable for use in animal models of chronic pain, which are commonly associated with hypersensitivity of the hind-paws. The aim of the present study was to develop and validate a novel passive-avoidance paradigm in rats, employing air-puff as the aversive stimulus, and to use this paradigm to assess aversive learning and memory in rat models of chronic inflammatory and neuropathic pain. Air-puff exposure produced a significant passive-avoidance and this response was attenuated following administration of scopolamine. Nerve-ligated rats and rats injected with complete Freund's adjuvant developed allodynia and hyperalgesia. Air-puff produced a significant passive-avoidance response in both chronic pain models. However, there was no difference in the response between either model and its respective control group. Thus, air-puff can be used as an alternative to foot-shock to induce a passive-avoidance response. The data generated using this model suggest that aversive learning and memory remain intact in the rat spinal nerve ligation and complete Freund's adjuvant models of chronic neuropathic and inflammatory pain, respectively. en_US
dc.format application/pdf en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Passive avoidance en_US
dc.subject Conditioned aversion en_US
dc.subject Learning en_US
dc.subject Memory en_US
dc.subject Chronic pain en_US
dc.subject Pharmacology & Therapeutics en_US
dc.title Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain en_US
dc.type Article en_US
dc.local.publishedsource http://dx.doi.org/10.1016/j.jneumeth.2011.10.024 en_US
dc.description.peer-reviewed peer-reviewed en_US
dc.contributor.funder HEA en_US

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