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Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala

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dc.contributor.author Rea, Kieran
dc.contributor.author Roche, Michelle
dc.contributor.author Finn, David P.
dc.date.accessioned 2012-01-20T10:55:35Z
dc.date.available 2012-01-20T10:55:35Z
dc.date.issued 2011-04
dc.identifier.citation Rea K, Roche M, Finn DP (2011). Modulation of conditioned fear, fear-conditioned analgesia and brain regional c-Fos expression following administration of muscimol into the rat basolateral amygdala. Journal of Pain, 12(6):712-21. en_US
dc.identifier.uri http://hdl.handle.net/10379/2498
dc.description.abstract Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear, and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA administration of the GABAA receptor agonist muscimol on the expression of conditioned-fear, formalin-evoked nociception, and fear-conditioned analgesia in rats, and the associated alterations in brain regional expression of the immediate early gene product and marker of neuronal activity, c-Fos. Formalin-evoked nociceptive behavior, conditioned-fear and fear-conditioned analgesia were apparent in animals receiving intra-BLA saline. Intra-BLA muscimol suppressed fear behavior and prevented fear-conditioned analgesia, but had no significant effect on the expression of formalin-evoked nociception. The suppression of fear behavior by intra-BLA muscimol was associated with increased c-Fos expression in the central nucleus of the amygdala (CeA) and throughout the periaqueductal grey (PAG). These intra-BLA muscimol-induced increases in c-Fos expression were abolished in rats receiving intraplantar formalin injection. These data suggest that alterations in neuronal activity in the CeA and PAG as a result of altered GABAergic signalling in the BLA may be involved in the behavioral expression of fear and associated analgesia. Furthermore, these alterations in neuronal activity are susceptible to modulation by formalin-evoked nociceptive input in a state-dependent manner. en_US
dc.format application/pdf en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Amygdala en_US
dc.subject Muscimol en_US
dc.subject GABA en_US
dc.subject Receptor en_US
dc.subject Fear en_US
dc.subject Pain en_US
dc.subject Analgesia en_US
dc.subject Rat en_US
dc.subject c-Fos en_US
dc.subject Pharmacology &Therapeutics en_US
dc.title Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala en_US
dc.type Article en_US
dc.local.publishedsource http://dx.doi.org/10.1016/j.jpain.2010.12.010 en_US
dc.description.peer-reviewed peer-reviewed en_US
dc.contributor.funder SFI en_US
dc.contributor.funder Irish Health Research Board en_US

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